The UniProt Knowledgebase (UniProtKB) is a comprehensive resource for protein sequence and functional information with extensive cross-references to more than 120 external databases. Besides amino acid sequence and a description, it also provides taxonomic data and citation information.

Prefix

uniprot

Alternative Prefixes

SwissProt UniProtKB UniProt UP Uniprot ID uniprot/swiss-prot

Keywords

biology protein taxonomic classification

License

CC-BY-4.0

Links

Homepage

Contact

Rolf Apweiler   0000-0001-7078-200X

Pattern for Local Unique Identifiers

Local identifiers in UniProt Protein should match this regular expression:
^([A-N,R-Z][0-9]([A-Z][A-Z, 0-9][A-Z, 0-9][0-9]){1,2})|([O,P,Q][0-9][A-Z, 0-9][A-Z, 0-9][A-Z, 0-9][0-9])(\.\d+)?$

Example Local Unique Identifier

P0DP23   Resolve

Pattern for CURIES

Compact URIs (CURIEs) constructed from UniProt Protein should match this regular expression:
^uniprot:([A-N,R-Z][0-9]([A-Z][A-Z, 0-9][A-Z, 0-9][0-9]){1,2})|([O,P,Q][0-9][A-Z, 0-9][A-Z, 0-9][A-Z, 0-9][0-9])(\.\d+)?$

Example CURIE

uniprot:P0DP23

Publications

• 2024 DescribePROT Database of Residue-Level Protein Structure and Function Annotations
• 2024 BFVD-a large repository of predicted viral protein structures
• 2024 UniProt: the Universal Protein Knowledgebase in 2025
• 2024 The O-GlcNAc database: introducing new features and tools developed from community feedback
• 2024 Autoinhibited Protein Database: a curated database of autoinhibitory domains and their autoinhibition mechanisms
• 2006 The Universal Protein Resource (UniProt): an expanding universe of protein information

Contributors

• contributor Mufaddal Naguthanawala   0009-0009-5240-7463   nagutm

A summary of the relations in the Bioregistry schema can be found here.

Provided By

apid.interactions bykdb compulyeast goa mobidb orthodb pina pmp repeatsdb.protein string swiss-model topfind

Has Parts (bfo:0000051 )

uniprot.chain uniprot.disease uniprot.isoform uniprot.keyword uniprot.location uniprot.proteome uniprot.ptm uniprot.resource uniprot.tissue uniprot.var

In Collection

Global Biodata Coalition - Global Core Biodata Resources

The metaregistry provides mappings between the Bioregistry and other registries. There are 15 mappings to external registries for this resource with 8 unique external prefixes.

When using this resource in RDF, the following URI format should be used:

http://purl.uniprot.org/uniprot/$1

A provider turns a local unique identifiers from a resource into a URI. Many providers are also resolvable as URLs (i.e., they can be used in a web browser).

The local unique identifier P0DP23 is used to demonstrate the providers available for UniProt Protein. A guide for curating additional providers can be found here.

Additional providers curated in the Bioregistry are listed here. These are typically inherited from Identifiers.org or Prefix Commons, and need extra curation.