The UniProt Knowledgebase (UniProtKB) is a comprehensive resource for protein sequence and functional information with extensive cross-references to more than 120 external databases. Besides amino acid sequence and a description, it also provides taxonomic data and citation information.

Prefix

uniprot

Alternative Prefixes

SwissProt UniProt UniProtKB Uniprot ID UP uniprot/swiss-prot

Keywords

biology ontology protein repository sequence taxonomic classification

License

CC-BY-4.0

Links

Homepage OBO OWL OBO JSON

Publications

2025 ProteinsPlus: a publicly available resource for protein structure mining

2024 DescribePROT Database of Residue-Level Protein Structure and Function Annotations

2024 BFVD-a large repository of predicted viral protein structures

2024 UniProt: the Universal Protein Knowledgebase in 2025

2024 The O-GlcNAc database: introducing new features and tools developed from community feedback

2024 Autoinhibited Protein Database: a curated database of autoinhibitory domains and their autoinhibition mechanisms

2006 The Universal Protein Resource (UniProt): an expanding universe of protein information

Pattern for Local Unique Identifiers

Local identifiers in UniProt Protein should match this regular expression:
^([A-N,R-Z][0-9]([A-Z][A-Z, 0-9][A-Z, 0-9][0-9]){1,2})|([O,P,Q][0-9][A-Z, 0-9][A-Z, 0-9][A-Z, 0-9][0-9])(\.\d+)?(-\d+)?(#PRO_\d+)?$

Example Local Unique Identifier

P0DP23   Resolve

Pattern for CURIES

Compact URIs (CURIEs) constructed from UniProt Protein should match this regular expression:
^uniprot:([A-N,R-Z][0-9]([A-Z][A-Z, 0-9][A-Z, 0-9][0-9]){1,2})|([O,P,Q][0-9][A-Z, 0-9][A-Z, 0-9][A-Z, 0-9][0-9])(\.\d+)?(-\d+)?(#PRO_\d+)?$

Example CURIE

uniprot:P0DP23

Pattern for RDF URIs

http://purl.uniprot.org/uniprot/$1

Example RDF URI

http://purl.uniprot.org/uniprot/P0DP23

Contact

Alex Bateman   0000-0002-6982-4660   bateman-research

Alan Bridge   0000-0003-2148-9135

Cathy Wu   0000-0001-6379-8601

Contributors

contributor Mufaddal Naguthanawala   0009-0009-5240-7463   nagutm

A summary of the relations in the Bioregistry schema can be found here.

Provided By

apid.interactions bykdb compulyeast goa mobidb orthodb pina pmp repeatsdb.protein string swiss-model topfind

In Collection (2)

Global Biodata Coalition - Global Core Biodata Resources Synapse.org external links

Mappings from records in Bioregistry to external registries comprises the metaregistry. This resource has 15 mappings to external registries with 8 unique external prefixes.

A provider turns a local unique identifiers from a resource into a URI. Many providers are also resolvable as URLs (i.e., they can be used in a web browser).

The local unique identifier P0DP23 is used to demonstrate the providers available for UniProt Protein. Some providers may use a different example, which is displayed in the table below. A guide for curating additional providers can be found here.

Additional providers curated in the Bioregistry are listed here. These are typically inherited from Identifiers.org or Prefix Commons, and need extra curation.