STRING (Search Tool for Retrieval of Interacting Genes/Proteins) is a database of known and predicted protein interactions. The interactions include direct (physical) and indirect (functional) associations; they are derived from four sources:Genomic Context, High-throughput Experiments,(Conserved) Coexpression, Previous Knowledge. STRING quantitatively integrates interaction data from these sources for a large number of organisms, and transfers information between these organisms where applicable.

This resource is a provider. This means that while it may have its own prefix, it actually reuses the identifiers provided by the uniprot prefix. For all use cases, you should use uniprot instead of string.

Prefix

string

Keywords

biology interaction life science protein

Links

Homepage

Contact

Peer Bork   0000-0002-2627-833X

Pattern for Local Unique Identifiers

Local identifiers in Search Tool for Retrieval of Interacting Genes/Proteins should match this regular expression:
^([A-N,R-Z][0-9][A-Z][A-Z, 0-9][A-Z, 0-9][0-9])|([O,P,Q][0-9][A-Z, 0-9][A-Z, 0-9][A-Z, 0-9][0-9])|([0-9][A-Za-z0-9]{3})$

Example Local Unique Identifier

P53350   Resolve

Pattern for CURIES

Compact URIs (CURIEs) constructed from Search Tool for Retrieval of Interacting Genes/Proteins should match this regular expression:
^string:([A-N,R-Z][0-9][A-Z][A-Z, 0-9][A-Z, 0-9][0-9])|([O,P,Q][0-9][A-Z, 0-9][A-Z, 0-9][A-Z, 0-9][0-9])|([0-9][A-Za-z0-9]{3})$

Example CURIE

string:P53350

Publications

• 2019 STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets.
• 2016 The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible.
• 2015 SVD-phy: improved prediction of protein functional associations through singular value decomposition of phylogenetic profiles.
• 2014 STRING v10: protein-protein interaction networks, integrated over the tree of life.
• 2012 STRING v9.1: protein-protein interaction networks, with increased coverage and integration.
• 2008 STRING 8--a global view on proteins and their functional interactions in 630 organisms.

Provides

uniprot

The metaregistry provides mappings between the Bioregistry and other registries. There are 8 mappings to external registries for string with 5 unique external prefixes.

Providers are various services that resolve CURIEs to URLs. The example CURIE string:P53350 is used to demonstrate the provides available for string. Generation of OLS and BioPortal URLs requires additional programmatic logic beyond string formatting.

Additional providers curated in the Bioregistry are listed here.