Rhea is an expert-curated knowledgebase of chemical and transport reactions of biological interest. Enzyme-catalyzed and spontaneously occurring reactions are curated from peer-reviewed literature and represented in a computationally tractable manner by using the ChEBI (Chemical Entities of Biological Interest) ontology to describe reaction participants. Rhea covers the reactions described by the IUBMB Enzyme Nomenclature as well as many additional reactions and can be used for enzyme annotation, genome-scale metabolic modeling and omics-related analyses. Rhea is the standard for enzyme and transporter annotation in UniProtKB.

Prefix

rhea

Alternative Prefixes

RHEA

Keywords

biochemistry life science reaction small molecule

Links

Homepage @rhea_db

Contact

Anne Morgat   0000-0002-1216-2969

Pattern for Local Unique Identifiers

Local identifiers in Rhea, the Annotated Reactions Database should match this regular expression:
^\d{5}$

Example Local Unique Identifier

12345   Resolve

Pattern for CURIES

Compact URIs (CURIEs) constructed from Rhea, the Annotated Reactions Database should match this regular expression:
^rhea:\d{5}$

Example CURIE

rhea:12345

Publications

• 2022 Rhea, the reaction knowledgebase in 2022.
• 2020 Enzyme annotation in UniProtKB using Rhea.
• 2019 Updates in Rhea: SPARQLing biochemical reaction data.
• 2016 Updates in Rhea - an expert curated resource of biochemical reactions.
• 2014 Updates in Rhea--a manually curated resource of biochemical reactions.
• 2011 Rhea--a manually curated resource of biochemical reactions.

The metaregistry provides mappings between the Bioregistry and other registries. There are 8 mappings to external registries for rhea with 4 unique external prefixes.

Providers are various services that resolve CURIEs to URLs. The example CURIE rhea:12345 is used to demonstrate the provides available for rhea. Generation of OLS and BioPortal URLs requires additional programmatic logic beyond string formatting.