Rhea is an expert-curated knowledgebase of chemical and transport reactions of biological interest. Enzyme-catalyzed and spontaneously occurring reactions are curated from peer-reviewed literature and represented in a computationally tractable manner by using the ChEBI (Chemical Entities of Biological Interest) ontology to describe reaction participants. Rhea covers the reactions described by the IUBMB Enzyme Nomenclature as well as many additional reactions and can be used for enzyme annotation, genome-scale metabolic modeling and omics-related analyses. Rhea is the standard for enzyme and transporter annotation in UniProtKB.
Local identifiers in Rhea, the Annotated Reactions Database should match this
Compact URIs (CURIEs) constructed from Rhea, the Annotated Reactions Database should match
this regular expression:
The metaregistry provides mappings between the Bioregistry and other registries. There are
6 mappings to external registries for
|Registry Name||Metaprefix||External Prefix|
|Gene Ontology Registry||
Providers are various services that resolve CURIEs to URLs. The example CURIE
is used to demonstrate the provides available for
rhea. Generation of OLS and BioPortal URLs requires additional programmatic
logic beyond string formatting.
|Rhea, the Annotated Reactions Database||