Registry Rhea, the Annotated Reactions Database

Rhea is an expert-curated knowledgebase of chemical and transport reactions of biological interest. Enzyme-catalyzed and spontaneously occurring reactions are curated from peer-reviewed literature and represented in a computationally tractable manner by using the ChEBI (Chemical Entities of Biological Interest) ontology to describe reaction participants. Rhea covers the reactions described by the IUBMB Enzyme Nomenclature as well as many additional reactions and can be used for enzyme annotation, genome-scale metabolic modeling and omics-related analyses. Rhea is the standard for enzyme and transporter annotation in UniProtKB.

Alternative Prefixes
biochemistry life science reaction small molecule
Homepage @rhea_db
Anne Morgat   0000-0002-1216-2969
Pattern for Local Unique Identifiers

Local identifiers in Rhea, the Annotated Reactions Database should match this regular expression:

Example Local Unique Identifier
12345   Resolve
Pattern for CURIES

Compact URIs (CURIEs) constructed from Rhea, the Annotated Reactions Database should match this regular expression:

Example CURIE
Metaregistry Rhea, the Annotated Reactions Database

The metaregistry provides mappings between the Bioregistry and other registries. There are 8 mappings to external registries for rhea with 4 unique external prefixes.

Registry Name Registry Metaprefix External Prefix Curate
BioContext biocontext RHEA
EDAM EDAM Ontology logo edam 2644
FAIRSharing FAIRSharing logo fairsharing FAIRsharing.pn1sr5
GO Gene Ontology Registry logo go RHEA logo miriam rhea
N2T Name-to-Thing logo n2t rhea
Prefix Commons Prefix Commons logo prefixcommons rhea
re3data Registry of Research Data Repositories logo re3data r3d100010891

Providers are various services that resolve CURIEs to URLs. The example CURIE rhea:12345 is used to demonstrate the provides available for rhea. Generation of OLS and BioPortal URLs requires additional programmatic logic beyond string formatting.

Name Metaprefix URI
Rhea, the Annotated Reactions Database rhea
Bioregistry bioregistry miriam
Name-to-Thing n2t