appears_in: []
depends_on: []
deprecated: false
description: 'Rhea is an expert-curated knowledgebase of chemical and transport reactions
  of biological interest. Enzyme-catalyzed and spontaneously occurring reactions are
  curated from peer-reviewed literature and represented in a computationally tractable
  manner by using the ChEBI (Chemical Entities of Biological Interest) ontology to
  describe reaction participants.


  Rhea covers the reactions described by the IUBMB Enzyme Nomenclature as well as
  many additional reactions and can be used for enzyme annotation, genome-scale metabolic
  modeling and omics-related analyses. Rhea is the standard for enzyme and transporter
  annotation in UniProtKB.'
download_json: https://w3id.org/biopragmatics/resources/rhea/rhea.json.gz
download_obo: https://w3id.org/biopragmatics/resources/rhea/rhea.obo
download_owl: https://w3id.org/biopragmatics/resources/rhea/rhea.owl.gz
example: '12345'
example_extras: []
homepage: https://www.rhea-db.org
keywords:
- biopax
- interaction/pathway
- metabolite
- ontology
- protein
- reaction
- small molecule
license: CC-BY-4.0
logo: https://www.rhea-db.org/style/images/rhea_logo.png
mappings:
  biocontext: RHEA
  edam: '2644'
  go: RHEA
  integbio: nbdc02083
  miriam: rhea
  n2t: rhea
  pathguide: '310'
  prefixcommons: rhea
  re3data: r3d100010891
  togoid: Rhea
  wikidata.entity: Q24265951
name: Rhea reaction
namespace_in_lui: false
pattern: ^\d{5}$
preferred_prefix: rhea
prefix: rhea
providers:
- code: bio2rdf
  description: Bio2RDF is an open-source project that uses Semantic Web technologies
    to build and provide the largest network of Linked Data for the Life Sciences.
    Bio2RDF defines a set of simple conventions to create RDF(S) compatible Linked
    Data from a diverse set of heterogeneously formatted sources obtained from multiple
    data providers.
  homepage: https://bio2rdf.org
  name: Bio2RDF
  uri_format: http://bio2rdf.org/rhea:$1
publications:
- doi: 10.1093/nar/gkab1016
  pmc: PMC8728268
  pubmed: '34755880'
  title: Rhea, the reaction knowledgebase in 2022
  year: 2022
- doi: 10.1093/bioinformatics/btz817
  pmc: PMC7162351
  pubmed: '31688925'
  title: Enzyme annotation in UniProtKB using Rhea
  year: 2020
- doi: 10.1093/nar/gky876
  pmc: PMC6324061
  pubmed: '30272209'
  title: 'Updates in Rhea: SPARQLing biochemical reaction data'
  year: 2019
- doi: 10.1093/nar/gkw990
  pmc: PMC5210663
  pubmed: '27789701'
  title: Updates in Rhea - an expert curated resource of biochemical reactions
  year: 2016
- doi: 10.1093/nar/gku961
  pmc: PMC4384025
  pubmed: '25332395'
  title: Updates in Rhea--a manually curated resource of biochemical reactions
  year: 2014
- doi: 10.1093/nar/gkr1126
  pmc: PMC3245052
  pubmed: '22135291'
  title: Rhea--a manually curated resource of biochemical reactions
  year: 2011
synonyms:
- RHEA
uri_format: https://www.rhea-db.org/rhea/$1
