Rhea is an expert-curated knowledgebase of chemical and transport reactions of biological interest. Enzyme-catalyzed and spontaneously occurring reactions are curated from peer-reviewed literature and represented in a computationally tractable manner by using the ChEBI (Chemical Entities of Biological Interest) ontology to describe reaction participants. Rhea covers the reactions described by the IUBMB Enzyme Nomenclature as well as many additional reactions and can be used for enzyme annotation, genome-scale metabolic modeling and omics-related analyses. Rhea is the standard for enzyme and transporter annotation in UniProtKB.

Prefix
rhea
Alternative Prefixes
RHEA
Keywords
biochemistry life science reaction small molecule
Links
Homepage
Contact
Anne Morgat   0000-0002-1216-2969
Pattern for Local Unique Identifiers

Local identifiers in Rhea, the Annotated Reactions Database should match this regular expression:
^\d{5}$

Example Local Unique Identifier
12345   Resolve
Pattern for CURIES

Compact URIs (CURIEs) constructed from Rhea, the Annotated Reactions Database should match this regular expression:
^rhea:\d{5}$

Example CURIE
rhea:12345
Publications
Ontology

A summary of the relations in the Bioregistry schema can be found here.

In Collection
Global Biodata Coalition - Global Core Biodata Resources
Metaregistry Rhea, the Annotated Reactions Database

The metaregistry provides mappings between the Bioregistry and other registries. There are 11 mappings to external registries for this resource with 6 unique external prefixes.

Registry Name Registry Metaprefix External Prefix Curate
BioContext biocontext RHEA
EDAM EDAM Ontology logo edam 2644
FAIRSharing FAIRSharing logo fairsharing FAIRsharing.pn1sr5
GO Gene Ontology Registry logo go RHEA
Integbio Integbio logo integbio nbdc02083
Identifiers.org Identifiers.org logo miriam rhea
N2T Name-to-Thing logo n2t rhea
Pathguide Pathguide logo pathguide 310
Prefix Commons Prefix Commons logo prefixcommons rhea
re3data Registry of Research Data Repositories logo re3data r3d100010891
TogoID togoid Rhea
Providers

A provider turns a local unique identifiers from a resource into a URI. Many providers are also resolvable as URLs (i.e., they can be used in a web browser).

The local unique identifier 12345 is used to demonstrate the providers available for Rhea, the Annotated Reactions Database. A guide for curating additional providers can be found here.

Name Metaprefix URI
Rhea, the Annotated Reactions Database rhea https://www.rhea-db.org/rhea/12345
Bioregistry bioregistry https://bioregistry.io/rhea:12345
Identifiers.org miriam https://identifiers.org/rhea:12345
Name-to-Thing n2t https://n2t.net/rhea:12345
Extra Providers

Additional providers curated in the Bioregistry are listed here. These are typically inherited from Identifiers.org or Prefix Commons, and need extra curation.

Code Name URL
bio2rdf Bio2RDF http://bio2rdf.org/rhea:12345