Elucidating the mechanism of toxicity is crucial in drug safety evaluations. TOXic Process Ontology (TXPO) systematizes a wide variety of terms involving toxicity courses and processes. The first version of TXPO focuses on liver toxicity. The TXPO contains an is-a hierarchy that is organized into three layers: the top layer contains general terms, mostly derived from the Basic Formal Ontology. The intermediate layer contains biomedical terms in OBO foundry from UBERON, Cell Ontology, NCBI Taxon, ChEBI, Gene Ontology, PATO, OGG, INOH, HINO, NCIT, DOID and Relational ontology (RO). The lower layer contains toxicological terms. In applied work, we have developed a prototype of TOXPILOT, a TOXic Process InterpretabLe knOwledge sysTem. TOXPILOT provides visualization maps of the toxic course, which facilitates capturing the comprehensive picture for understanding toxicity mechanisms. A prototype of TOXPILOT is available: https://toxpilot.nibiohn.go.jp
txpo
TXPO
Local identifiers in Toxic Process Ontology should match this
regular expression:
^\d{7}$
Compact URIs (CURIEs) constructed from Toxic Process Ontology should match
this regular expression:
^txpo:\d{7}$
The metaregistry provides mappings between the Bioregistry and other registries. There are
5 mappings to external registries for txpo
with
1 unique external prefixes.
Registry Name | Registry Metaprefix | External Prefix | Curate |
---|---|---|---|
AberOWL
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aberowl |
TXPO
|
|
BioPortal
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bioportal |
TXPO
|
|
OBO Foundry
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obofoundry |
txpo
|
|
OLS
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ols |
txpo
|
|
OntoBee
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ontobee |
TXPO
|
When using this resource in RDF, the following URI format should be used:
http://purl.obolibrary.org/obo/TXPO_$1
Providers are various services that resolve CURIEs to URLs. The example CURIE
txpo:0002066
is used to demonstrate the provides available for
txpo
. Generation of OLS and BioPortal URLs requires additional programmatic
logic beyond string formatting.