Elucidating the mechanism of toxicity is crucial in drug safety evaluations. TOXic Process Ontology (TXPO) systematizes a wide variety of terms involving toxicity courses and processes. The first version of TXPO focuses on liver toxicity. The TXPO contains an is-a hierarchy that is organized into three layers: the top layer contains general terms, mostly derived from the Basic Formal Ontology. The intermediate layer contains biomedical terms in OBO foundry from UBERON, Cell Ontology, NCBI Taxon, ChEBI, Gene Ontology, PATO, OGG, INOH, HINO, NCIT, DOID and Relational ontology (RO). The lower layer contains toxicological terms. In applied work, we have developed a prototype of TOXPILOT, a TOXic Process InterpretabLe knOwledge sysTem. TOXPILOT provides visualization maps of the toxic course, which facilitates capturing the comprehensive picture for understanding toxicity mechanisms. A prototype of TOXPILOT is available: https://toxpilot.nibiohn.go.jp

Prefix

txpo

Preferred Prefix

TXPO

Keywords

obo ontology

Version

2022-12-07

License

CC-BY-3.0

Links

Homepage Repository OWL

Contact

Yuki Yamagata   0000-0002-9673-1283   yuki-yamagata

Pattern for Local Unique Identifiers

Local identifiers in Toxic Process Ontology should match this regular expression:
^\d{7}$

Example Local Unique Identifier

0002066   Resolve

Pattern for CURIES

Compact URIs (CURIEs) constructed from Toxic Process Ontology should match this regular expression:
^txpo:\d{7}$

Example CURIE

txpo:0002066

Publications

2020 Ontological approach to the knowledge systematization of a toxic process and toxic course representation framework for early drug risk management.

The metaregistry provides mappings between the Bioregistry and other registries. There are 5 mappings to external registries for txpo with 1 unique external prefixes.

When using this resource in RDF, the following URI format should be used:

http://purl.obolibrary.org/obo/TXPO_$1

Providers are various services that resolve CURIEs to URLs. The example CURIE txpo:0002066 is used to demonstrate the provides available for txpo. Generation of OLS and BioPortal URLs requires additional programmatic logic beyond string formatting.