appears_in: []
contact:
  email: yuki.yamagata@riken.jp
  github: yuki-yamagata
  name: Yuki Yamagata
  orcid: 0000-0002-9673-1283
depends_on: []
deprecated: false
description: 'Elucidating the mechanism of toxicity is crucial in drug safety evaluations.
  TOXic Process Ontology (TXPO) systematizes a wide variety of terms involving toxicity
  courses and processes. The first version of TXPO focuses on liver toxicity.


  The TXPO contains an is-a hierarchy that is organized into three layers: the top
  layer contains general terms, mostly derived from the Basic Formal Ontology. The
  intermediate layer contains biomedical terms in OBO foundry from UBERON, Cell Ontology,
  NCBI Taxon, ChEBI, Gene Ontology, PATO, OGG, INOH, HINO, NCIT, DOID and Relational
  ontology (RO). The lower layer contains toxicological terms.


  In applied work, we have developed a prototype of TOXPILOT, a TOXic Process InterpretabLe
  knOwledge sysTem. TOXPILOT provides visualization maps of the toxic course, which
  facilitates capturing the comprehensive picture for understanding toxicity mechanisms.
  A prototype of TOXPILOT is available: https://toxpilot.nibiohn.go.jp'
download_owl: http://purl.obolibrary.org/obo/txpo.owl
example: '0002066'
example_extras: []
homepage: https://toxpilot.nibiohn.go.jp/
keywords:
- obo
- ontology
license: CC-BY-3.0
mappings:
  aberowl: TXPO
  bioportal: TXPO
  obofoundry: txpo
  ols: txpo
  ontobee: TXPO
name: Toxic Process Ontology
pattern: ^\d{7}$
preferred_prefix: TXPO
prefix: txpo
providers: []
publications:
- doi: 10.1038/s41598-020-71370-7
  pmc: PMC7471325
  pubmed: '32883995'
  title: Ontological approach to the knowledge systematization of a toxic process
    and toxic course representation framework for early drug risk management
  year: 2020
rdf_uri_format: http://purl.obolibrary.org/obo/TXPO_$1
repository: https://github.com/txpo-ontology/TXPO
synonyms: []
uri_format: http://purl.obolibrary.org/obo/TXPO_$1
version: '2022-12-07'
