CATH is a classification of protein structural domains. We group protein domains into superfamilies when there is sufficient evidence they have diverged from a common ancestor. CATH can be used to predict structural and functional information directly from protein sequence.

Prefix

cath

Keywords

biology classification evolutionary biology protein structure

Links

Homepage @CATHDatabase

Contact

Missing Contact

Pattern for Local Unique Identifiers

Local identifiers in CATH Protein Structural Domain Superfamily should match this regular expression:
^[1-6]\.[0-9]+\.[0-9]+\.[0-9]+$

Example Local Unique Identifier

1.10.8.10   Resolve

Pattern for CURIES

Compact URIs (CURIEs) constructed from CATH Protein Structural Domain Superfamily should match this regular expression:
^cath:[1-6]\.[0-9]+\.[0-9]+\.[0-9]+$

Example CURIE

cath:1.10.8.10

Publications

• 1997 CATH--a hierarchic classification of protein domain structures.
• 2021 CATH: increased structural coverage of functional space.
• 2019 CATH: expanding the horizons of structure-based functional annotations for genome sequences.
• 2018 Gene3D: Extensive prediction of globular domains in proteins.
• 2016 CATH: an expanded resource to predict protein function through structure and sequence.
• 2016 Functional classification of CATH superfamilies: a domain-based approach for protein function annotation.
• 2015 The history of the CATH structural classification of protein domains.
• 2014 CATH: comprehensive structural and functional annotations for genome sequences.
• 2002 The CATH protein family database: a resource for structural and functional annotation of genomes.

Has Part

cath.superfamily

The metaregistry provides mappings between the Bioregistry and other registries. There are 7 mappings to external registries for cath with 4 unique external prefixes.

Providers are various services that resolve CURIEs to URLs. The example CURIE cath:1.10.8.10 is used to demonstrate the provides available for cath. Generation of OLS and BioPortal URLs requires additional programmatic logic beyond string formatting.