The Rfam database is a collection of RNA families, each represented by multiple sequence alignments, consensus secondary structures and covariance models (CMs). The families in Rfam break down into three broad functional classes: non-coding RNA genes, structured cis-regulatory elements and self-splicing RNAs. Typically these functional RNAs often have a conserved secondary structure which may be better preserved than the RNA sequence. The CMs used to describe each family are a slightly more complicated relative of the profile hidden Markov models (HMMs) used by Pfam. CMs can simultaneously model RNA sequence and the structure in an elegant and accurate fashion.
Local identifiers in Rfam database of RNA families should match this
Compact URIs (CURIEs) constructed from Rfam database of RNA families should match
this regular expression:
The metaregistry provides mappings between the Bioregistry and other registries. There are
7 mappings to external registries for
3 unique external prefixes.
|Registry Name||Registry Metaprefix||External Prefix||Curate|
|Gene Ontology Registry||
|National Center for Biotechnology Information Registry||
Providers are various services that resolve CURIEs to URLs. The example CURIE
is used to demonstrate the provides available for
rfam. Generation of OLS and BioPortal URLs requires additional programmatic
logic beyond string formatting.
|Rfam database of RNA families||