appears_in: []
contact:
  email: apetrov@ebi.ac.uk
  github: AntonPetrov
  name: Anton I Petrov
  orcid: 0000-0001-7279-2682
depends_on: []
deprecated: false
description: 'The Rfam database is a collection of RNA families, each represented
  by multiple sequence alignments, consensus secondary structures and covariance models
  (CMs). The families in Rfam break down into three broad functional classes: non-coding
  RNA genes, structured cis-regulatory elements and self-splicing RNAs. Typically
  these functional RNAs often have a conserved secondary structure which may be better
  preserved than the RNA sequence. The CMs used to describe each family are a slightly
  more complicated relative of the profile hidden Markov models (HMMs) used by Pfam.
  CMs can simultaneously model RNA sequence and the structure in an elegant and accurate
  fashion.'
example: RF00230
example_extras: []
homepage: https://rfam.xfam.org/
keywords:
- bibliography/documents
- classification
- rna
- sequence
- transcript
mappings:
  biocontext: RFAM
  edam: '2356'
  go: Rfam
  integbio: nbdc00654
  miriam: rfam
  n2t: rfam
  ncbi: RFAM
  togoid: Rfam
  wikidata: P3523
name: Rfam ID
namespace_in_lui: false
pattern: ^RF\d{5}$
preferred_prefix: rfam
prefix: rfam
providers: []
publications:
- doi: 10.1093/nar/gkae1023
  pubmed: '39526405'
  title: 'Rfam 15: RNA families database in 2025'
  year: 2024
- doi: 10.1093/nar/gkx1038
  pmc: PMC5753348
  pubmed: '29112718'
  title: 'Rfam 13.0: shifting to a genome-centric resource for non-coding RNA families'
  year: 2018
- doi: 10.1093/nar/gku1063
  pmc: PMC4383904
  pubmed: '25392425'
  title: 'Rfam 12.0: updates to the RNA families database'
  year: 2014
- pubmed: '21062808'
- pubmed: '18953034'
- pubmed: '18945806'
- pubmed: '15608160'
- pubmed: '12520045'
synonyms: []
uri_format: https://rfam.org/family/$1
