The need of a common ontology for describing orthology information in biological research communities has led to the creation of the Orthology Ontology (ORTH). ORTH ontology is designed to describe sequence homology data available in multiple orthology databases on the Web (e.g.: OMA, OrthoDB, HieranoiDB, and etc.). By sequence homology data, we mostly mean gene region, gene and protein centric orthology, paralogy, and xenology information. Depending on the database, the homology information is structured in different ways. ORTH ontology accommodates these disparate data structures namely Hierarchical Orthologous Group (HOG), cluster of homologous sequences and homologous-pairwise relations between sequences. In addition to the specific ORTH terms, this specification includes terms of the imported ontologies (e.g. Semanticscience Integrated Ontology, SIO) which are pertinents to represent the information from various orthology databases in a homogeneous way.

comparative genomics gene homologous ontology orthologous paralogous protein sequence
Homepage Repository OWL
Jesualdo Tomás Fernández-Breis   0000-0002-7558-2880   jesualdotomasfernandezbreis
Pattern for Local Unique Identifiers
Missing LUI pattern
Example Local Unique Identifier
HomologyRelation   Resolve
Example CURIE
2016 The Orthology Ontology: development and applications
Metaregistry Orthology Ontology

The metaregistry provides mappings between the Bioregistry and other registries. There are 4 mappings to external registries for this resource with 2 unique external prefixes.

Registry Name Registry Metaprefix External Prefix Curate
AberOWL AberOWL logo aberowl ORTH
BioPortal BioPortal Prefixes logo bioportal ORTH
FAIRSharing FAIRSharing logo fairsharing FAIRsharing.4877h0
OLS Ontology Lookup Service logo ols orth

A provider turns a local unique identifiers from a resource into a URI. Many providers are also resolvable as URLs (i.e., they can be used in a web browser).

The local unique identifier HomologyRelation is used to demonstrate the providers available for Orthology Ontology. A guide for curating additional providers can be found here.

Name Metaprefix URI
Orthology Ontology orth
Bioregistry bioregistry