The need of a common ontology for describing orthology information in biological research communities has led to the creation of the Orthology Ontology (ORTH). ORTH ontology is designed to describe sequence homology data available in multiple orthology databases on the Web (e.g.: OMA, OrthoDB, HieranoiDB, and etc.). By sequence homology data, we mostly mean gene region, gene and protein centric orthology, paralogy, and xenology information. Depending on the database, the homology information is structured in different ways. ORTH ontology accommodates these disparate data structures namely Hierarchical Orthologous Group (HOG), cluster of homologous sequences and homologous-pairwise relations between sequences. In addition to the specific ORTH terms, this specification includes terms of the imported ontologies (e.g. Semanticscience Integrated Ontology, SIO) which are pertinents to represent the information from various orthology databases in a homogeneous way.

This ontology is the second version of the orthology ontology first published in 2015 and available at . @authors T.M. de Farias, H. Chiba, J.T. Fernandez-Breis, E. Antezana, D. Kuznetsov, C. Dessimoz and F. Villiers.
Homepage Repository OWL
Jesualdo Tomás Fernández-Breis   0000-0002-7558-2880   jesualdotomasfernandezbreis
Pattern for Local Unique Identifiers
Missing LUI pattern
Example Local Unique Identifier
HomologyRelation   Resolve
Pattern for CURIES
Could not construct CURIE pattern
Example CURIE
2016 The Orthology Ontology: development and applications.
Metaregistry Orthology Ontology

The metaregistry provides mappings between the Bioregistry and other registries. There are 4 mappings to external registries for orth with 2 unique external prefixes.

Registry Name Registry Metaprefix External Prefix Curate
AberOWL aberowl ORTH
BioPortal Prefixes bioportal ORTH
FAIRSharing FAIRSharing logo fairsharing FAIRsharing.4877h0
Ontology Lookup Service Ontology Lookup Service logo ols orth

Providers are various services that resolve CURIEs to URLs. The example CURIE orth:HomologyRelation is used to demonstrate the provides available for orth. Generation of OLS and BioPortal URLs requires additional programmatic logic beyond string formatting.

Name Metaprefix URI
Orthology Ontology orth
Bioregistry bioregistry