CIViC variants are usually genomic alterations, including single nucleotide variants (SNVs), insertion/deletion events (indels), copy number alterations (CNV’s such as amplification or deletion), structural variants (SVs such as translocations and inversions), and other events that differ from the “normal” genome. In some cases a CIViC variant may represent events of the transcriptome or proteome. For example, ‘expression’ or ‘over-expression’ is a valid variant. Regardless of the variant, it must have a Predictive, Prognostic, Predisposing, Diagnostic, Oncogenic, or Functional relevance that is clinical in nature to be entered in CIViC. i.e. There must be some rationale for why curation of this variant could ultimately aid clinical decision making.
Local identifiers in CIViC variant ID should match this
Compact URIs (CURIEs) constructed from CIViC variant ID should match
this regular expression:
The metaregistry provides mappings between the Bioregistry and other registries. There are
2 mappings to external registries for
2 unique external prefixes.
|Registry Name||Registry Metaprefix||External Prefix||Curate|
Providers are various services that resolve CURIEs to URLs. The example CURIE
is used to demonstrate the provides available for
civic.vid. Generation of OLS and BioPortal URLs requires additional programmatic
logic beyond string formatting.
|CIViC variant ID||