Evidence Items are the central building block of the Clinical Interpretation of Variants in Cancer (CIViC) knowledgebase. The clinical Evidence Item is a piece of information that has been manually curated from trustable medical literature about a Variant or genomic ‘event’ that has implications in cancer Predisposition, Diagnosis (aka molecular classification), Prognosis, Predictive response to therapy, Oncogenicity or protein Function. For example, an Evidence Item might describe a line of evidence supporting the notion that tumors with a somatic BRAF V600 mutation generally respond well to the drug dabrafenib. A Variant may be a single nucleotide substitution, a small insertion or deletion, an RNA gene fusion, a chromosomal rearrangement, an RNA expression pattern (e.g. over-expression), etc. Each clinical Evidence statement corresponds to a single citable Source (a publication or conference abstract).

Missing Contact
Pattern for Local Unique Identifiers

Local identifiers in CIViC Evidence should match this regular expression:

Example Local Unique Identifier
1199   Resolve
Pattern for CURIES

Compact URIs (CURIEs) constructed from CIViC Evidence should match this regular expression:

Example CURIE

A summary of the relations in the Bioregistry schema can be found here.

Part Of (bfo:0000050 )
civic (not directly registered)
In Collection
Global Biodata Coalition - Global Core Biodata Resources
Metaregistry CIViC Evidence

The metaregistry provides mappings between the Bioregistry and other registries. There are 1 mappings to external registries for this resource with 1 unique external prefixes.

Registry Name Registry Metaprefix External Prefix Curate
Identifiers.org Identifiers.org logo miriam civic.eid

Providers are various services that resolve CURIEs to URLs. The example CURIE civic.eid:1199 is used to demonstrate the provides available for this resource. Generation of OLS and BioPortal URLs requires additional programmatic logic beyond string formatting.

Name Metaprefix URI
CIViC Evidence civic.eid https://civicdb.org/links/evidence/1199
Bioregistry bioregistry https://bioregistry.io/civic.eid:1199
Identifiers.org miriam https://identifiers.org/civic.eid:1199