Evidence Items are the central building block of the Clinical Interpretation of Variants in Cancer (CIViC) knowledgebase. The clinical Evidence Item is a piece of information that has been manually curated from trustable medical literature about a Variant or genomic ‘event’ that has implications in cancer Predisposition, Diagnosis (aka molecular classification), Prognosis, Predictive response to therapy, Oncogenicity or protein Function. For example, an Evidence Item might describe a line of evidence supporting the notion that tumors with a somatic BRAF V600 mutation generally respond well to the drug dabrafenib. A Variant may be a single nucleotide substitution, a small insertion or deletion, an RNA gene fusion, a chromosomal rearrangement, an RNA expression pattern (e.g. over-expression), etc. Each clinical Evidence statement corresponds to a single citable Source (a publication or conference abstract).
civic.eid
Local identifiers in CIViC Evidence should match this
regular expression:
^[0-9]+$
Compact URIs (CURIEs) constructed from CIViC Evidence should match
this regular expression:
^civic\.eid:[0-9]+$
bfo:0000050
)
The metaregistry provides mappings between the Bioregistry and other registries. There are
1 mappings to external registries for civic.eid
with
1 unique external prefixes.
Registry Name | Registry Metaprefix | External Prefix | Curate |
---|---|---|---|
Identifiers.org
![]() |
miriam |
civic.eid
|
Providers are various services that resolve CURIEs to URLs. The example CURIE
civic.eid:1199
is used to demonstrate the provides available for
civic.eid
. Generation of OLS and BioPortal URLs requires additional programmatic
logic beyond string formatting.
Name | Metaprefix | URI |
---|---|---|
CIViC Evidence | civic.eid |
https://civicdb.org/links/evidence/1199 |
Bioregistry | bioregistry |
https://bioregistry.io/civic.eid:1199 |
Identifiers.org | miriam |
https://identifiers.org/civic.eid:1199 |