Evidence Items are the central building block of the Clinical Interpretation of Variants in Cancer (CIViC) knowledgebase. The clinical Evidence Item is a piece of information that has been manually curated from trustable medical literature about a Variant or genomic ‘event’ that has implications in cancer Predisposition, Diagnosis (aka molecular classification), Prognosis, Predictive response to therapy, Oncogenicity or protein Function. For example, an Evidence Item might describe a line of evidence supporting the notion that tumors with a somatic BRAF V600 mutation generally respond well to the drug dabrafenib. A Variant may be a single nucleotide substitution, a small insertion or deletion, an RNA gene fusion, a chromosomal rearrangement, an RNA expression pattern (e.g. over-expression), etc. Each clinical Evidence statement corresponds to a single citable Source (a publication or conference abstract).
Local identifiers in CIViC Evidence should match this
Compact URIs (CURIEs) constructed from CIViC Evidence should match
this regular expression:
The metaregistry provides mappings between the Bioregistry and other registries. There are
1 mappings to external registries for
1 unique external prefixes.
|Registry Name||Metaprefix||External Prefix|
Providers are various services that resolve CURIEs to URLs. The example CURIE
is used to demonstrate the provides available for
civic.eid. Generation of OLS and BioPortal URLs requires additional programmatic
logic beyond string formatting.