An ontology of histopathological morphologies used by pathologists to classify/categorise animal lesions observed histologically during regulatory toxicology studies. The ontology was developed using real data from over 6000 regulatory toxicology studies donated by 13 companies spanning nine species.

The original structure of the histopathology ontology was designed ab initio when the INHAND manuscripts were not available. However, the ontology has been repetitively reviewed and updated to align with the subsequently published INHAND manuscripts. During this process cross references to INHAND lesion identifiers were added to the ontology. [from GitHub]


This ontology used to be available in OLS3, but is no longer available in OLS4.

The URI format string in this resource takes the form of an OBO PURL, but it is not itself registered with the OBO Foundry, and terms therefore redirect into This happens because the data is curated natively in the OBO Flat File Format from which CURIEs are automatically assumed to expand to OBO PURLs

Alternative Prefixes
Homepage Repository OBO
Carlo Ravagli   0000-0001-8372-8387   carloravagli
Pattern for Local Unique Identifiers

Local identifiers in Histopathology Ontology should match this regular expression:

Example Local Unique Identifier
2000191   Resolve
Pattern for CURIES

Compact URIs (CURIEs) constructed from Histopathology Ontology should match this regular expression:

Example CURIE
GitHub Issue

Providers are various services that resolve CURIEs to URLs. The example CURIE hpath:2000191 is used to demonstrate the provides available for this resource. Generation of OLS and BioPortal URLs requires additional programmatic logic beyond string formatting.

Name Metaprefix URI
Histopathology Ontology hpath
Bioregistry bioregistry