COGs stands for Clusters of Orthologous Genes. The database was initially created in 1997 (Tatusov et al., PMID: 9381173) followed by several updates, most recently in 2014 (Galperin et al., PMID: 25428365). The current update includes complete genomes of 1,187 bacteria and 122 archaea that map into 1,234 genera. The new features include ~250 updated COG annotations with corresponding references and PDB links, where available; new COGs for proteins involved in CRISPR-Cas immunity, sporulation, and photosynthesis, and the lists of COGs grouped by pathways and functional systems.
Local identifiers in Cluster of orthologous genes should match this
Compact URIs (CURIEs) constructed from Cluster of orthologous genes should match
this regular expression:
The metaregistry provides mappings between the Bioregistry and other registries. There are
3 mappings to external registries for
|Registry Name||Metaprefix||External Prefix|
|Biolink Model Registry||
|Gene Ontology Registry||
Providers are various services that resolve CURIEs to URLs. The example CURIE
cog:COG0001 is used to demonstrate the provides available for
cog. Generation of OLS and BioPortal URLs requires additional programmatic
logic beyond string formatting.
|Cluster of orthologous genes||