COGs stands for Clusters of Orthologous Genes. The database was initially created in 1997 (Tatusov et al., PMID: 9381173) followed by several updates, most recently in 2014 (Galperin et al., PMID: 25428365). The current update includes complete genomes of 1,187 bacteria and 122 archaea that map into 1,234 genera. The new features include ~250 updated COG annotations with corresponding references and PDB links, where available; new COGs for proteins involved in CRISPR-Cas immunity, sporulation, and photosynthesis, and the lists of COGs grouped by pathways and functional systems.

Prefix

cog

Alternative Prefixes

COG_Cluster

Keywords

genome life science protein

Links

Homepage

Contact

Michael Y Galperin   0000-0002-2265-5572

Pattern for Local Unique Identifiers

Local identifiers in Cluster of orthologous genes should match this regular expression:
^COG\d+$

Example Local Unique Identifier

COG0001   Resolve

Pattern for CURIES

Compact URIs (CURIEs) constructed from Cluster of orthologous genes should match this regular expression:
^cog:COG\d+$

Example CURIE

cog:COG0001

Publications

• 1997 A genomic perspective on protein families.
• 2014 Expanded microbial genome coverage and improved protein family annotation in the COG database.

Contributors

• submitter Charles Tapley Hoyt   0000-0003-4423-4370   cthoyt

Has Part

cog.category cog.pathway

The metaregistry provides mappings between the Bioregistry and other registries. There are 4 mappings to external registries for cog with 3 unique external prefixes.

Providers are various services that resolve CURIEs to URLs. The example CURIE cog:COG0001 is used to demonstrate the provides available for cog. Generation of OLS and BioPortal URLs requires additional programmatic logic beyond string formatting.