Registry Cluster of orthologous genes

COGs stands for Clusters of Orthologous Genes. The database was initially created in 1997 (Tatusov et al., PMID: 9381173) followed by several updates, most recently in 2014 (Galperin et al., PMID: 25428365). The current update includes complete genomes of 1,187 bacteria and 122 archaea that map into 1,234 genera. The new features include ~250 updated COG annotations with corresponding references and PDB links, where available; new COGs for proteins involved in CRISPR-Cas immunity, sporulation, and photosynthesis, and the lists of COGs grouped by pathways and functional systems.

Alternative Prefixes
Pattern for Local Unique Identifiers

Local identifiers in Cluster of orthologous genes should match this regular expression:

Example Local Unique Identifier
COG0001   Resolve
Pattern for CURIES

Compact URIs (CURIEs) constructed from Cluster of orthologous genes should match this regular expression:

Example CURIE

The metaregistry provides mappings between the Bioregistry and other registries. There are 2 mappings to external registries for cog.

Registry Name Metaprefix External Prefix
Biolink Model Registry biolink COG
Gene Ontology Registry go COG_Cluster

Providers are various services that resolve CURIEs to URLs. The example CURIE cog:COG0001 is used to demonstrate the provides available for cog. Generation of OLS and BioPortal URLs requires additional programmatic logic beyond string formatting.

Name Metaprefix URI
Cluster of orthologous genes cog
Bioregistry bioregistry