COGs stands for Clusters of Orthologous Genes. The database was initially created in 1997 (Tatusov et al., PMID: 9381173) followed by several updates, most recently in 2014 (Galperin et al., PMID: 25428365). The current update includes complete genomes of 1,187 bacteria and 122 archaea that map into 1,234 genera. The new features include ~250 updated COG annotations with corresponding references and PDB links, where available; new COGs for proteins involved in CRISPR-Cas immunity, sporulation, and photosynthesis, and the lists of COGs grouped by pathways and functional systems.

Prefix

cog

Alternative Prefixes

COG_Cluster

Keywords

genome life science protein

Links

Homepage

Contact

Michael Y Galperin   0000-0002-2265-5572

Pattern for Local Unique Identifiers

Local identifiers in Cluster of orthologous genes should match this regular expression:
^COG\d+$

Example Local Unique Identifier

COG0001   Resolve

Pattern for CURIES

Compact URIs (CURIEs) constructed from Cluster of orthologous genes should match this regular expression:
^cog:COG\d+$

Example CURIE

cog:COG0001

Publications

• 1997 A genomic perspective on protein families
• 2014 Expanded microbial genome coverage and improved protein family annotation in the COG database

Contributors

• submitter Charles Tapley Hoyt   0000-0003-4423-4370   cthoyt

A summary of the relations in the Bioregistry schema can be found here.

Has Parts (bfo:0000051 )

cog.category cog.pathway

The metaregistry provides mappings between the Bioregistry and other registries. There are 5 mappings to external registries for this resource with 3 unique external prefixes.

Providers are various services that resolve CURIEs to URLs. The example CURIE cog:COG0001 is used to demonstrate the provides available for this resource. Generation of OLS and BioPortal URLs requires additional programmatic logic beyond string formatting.

Additional providers curated in the Bioregistry are listed here.