COGs stands for Clusters of Orthologous Genes. The database was initially created in 1997 (Tatusov et al., PMID: 9381173) followed by several updates, most recently in 2014 (Galperin et al., PMID: 25428365). The current update includes complete genomes of 1,187 bacteria and 122 archaea that map into 1,234 genera. The new features include ~250 updated COG annotations with corresponding references and PDB links, where available; new COGs for proteins involved in CRISPR-Cas immunity, sporulation, and photosynthesis, and the lists of COGs grouped by pathways and functional systems.
cog
Local identifiers in Cluster of orthologous genes should match this
regular expression:
^COG\d+$
Compact URIs (CURIEs) constructed from Cluster of orthologous genes should match
this regular expression:
^cog:COG\d+$
A summary of the relations in the Bioregistry schema can be found here.
bfo:0000051
)
The metaregistry provides mappings between the Bioregistry and other registries. There are 5 mappings to external registries for this resource with 3 unique external prefixes.
Registry Name | Registry Metaprefix | External Prefix | Curate |
---|---|---|---|
Biolink
|
biolink |
COG
|
|
FAIRSharing
|
fairsharing |
FAIRsharing.djsbw2
|
|
GO
![]() |
go |
COG_Cluster
|
|
Identifiers.org
![]() |
miriam |
cog
|
|
Prefix Commons
|
prefixcommons |
cog
|
Providers are various services that resolve CURIEs to URLs. The example CURIE
cog:COG0001
is used to demonstrate the provides available for
this resource. Generation of OLS and BioPortal URLs requires additional programmatic
logic beyond string formatting.
Name | Metaprefix | URI |
---|---|---|
Cluster of orthologous genes | cog |
https://www.ncbi.nlm.nih.gov/research/cog/cog/COG0001 |
Bioregistry | bioregistry |
https://bioregistry.io/cog:COG0001 |
Identifiers.org | miriam |
https://identifiers.org/cog:COG0001 |
Additional providers curated in the Bioregistry are listed here.
Code | Name | URL |
---|---|---|
bio2rdf |
Bio2RDF | http://bio2rdf.org/cog:COG0001 |