The Rfam database is a collection of RNA families, each represented by multiple sequence alignments, consensus secondary structures and covariance models (CMs). The families in Rfam break down into three broad functional classes: non-coding RNA genes, structured cis-regulatory elements and self-splicing RNAs. Typically these functional RNAs often have a conserved secondary structure which may be better preserved than the RNA sequence. The CMs used to describe each family are a slightly more complicated relative of the profile hidden Markov models (HMMs) used by Pfam. CMs can simultaneously model RNA sequence and the structure in an elegant and accurate fashion.

Prefix

rfam

Keywords

genetics

Links

Homepage

Contact

Anton I Petrov   0000-0001-7279-2682   AntonPetrov

Pattern for Local Unique Identifiers

Local identifiers in Rfam database of RNA families should match this regular expression:
^RF\d{5}$

Example Local Unique Identifier

RF00230   Resolve

Pattern for CURIES

Compact URIs (CURIEs) constructed from Rfam database of RNA families should match this regular expression:
^rfam:RF\d{5}$

Example CURIE

rfam:RF00230

Publications

• 2018 Rfam 13.0: shifting to a genome-centric resource for non-coding RNA families
• 2014 Rfam 12.0: updates to the RNA families database

The metaregistry provides mappings between the Bioregistry and other registries. There are 8 mappings to external registries for this resource with 4 unique external prefixes.

A provider turns a local unique identifiers from a resource into a URI. Many providers are also resolvable as URLs (i.e., they can be used in a web browser).

The local unique identifier RF00230 is used to demonstrate the providers available for Rfam database of RNA families. A guide for curating additional providers can be found here.