The need of a common ontology for describing orthology information in biological research communities has led to the creation of the Orthology Ontology (ORTH). ORTH ontology is designed to describe sequence homology data available in multiple orthology databases on the Web (e.g.: OMA, OrthoDB, HieranoiDB, and etc.). By sequence homology data, we mostly mean gene region, gene and protein centric orthology, paralogy, and xenology information. Depending on the database, the homology information is structured in different ways. ORTH ontology accommodates these disparate data structures namely Hierarchical Orthologous Group (HOG), cluster of homologous sequences and homologous-pairwise relations between sequences. In addition to the specific ORTH terms, this specification includes terms of the imported ontologies (e.g. Semanticscience Integrated Ontology, SIO) which are pertinents to represent the information from various orthology databases in a homogeneous way.

Prefix

orth

Keywords

comparative genomics gene homologous ontology orthologous paralogous protein sequence

Version

2.0

Links

Homepage Repository OWL

Contact

Jesualdo Tomás Fernández-Breis   0000-0002-7558-2880   jesualdotomasfernandezbreis

Pattern for Local Unique Identifiers

Missing LUI pattern

Example Local Unique Identifier

HomologyRelation   Resolve

Example CURIE

orth:HomologyRelation

Publications

2016 The Orthology Ontology: development and applications

The metaregistry provides mappings between the Bioregistry and other registries. There are 4 mappings to external registries for this resource with 2 unique external prefixes.

A provider turns a local unique identifiers from a resource into a URI. Many providers are also resolvable as URLs (i.e., they can be used in a web browser).

The local unique identifier HomologyRelation is used to demonstrate the providers available for Orthology Ontology. A guide for curating additional providers can be found here.