Gene
fabp2
- ID
- ZDB-GENE-991019-5
- Name
- fatty acid binding protein 2, intestinal
- Symbol
- fabp2 Nomenclature History
- Previous Names
-
- I-FABP
- ifabp
- intestinal fatty acid binding protein
- zgc:92264
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable long-chain fatty acid binding activity. Acts upstream of or within cholesterol homeostasis; response to lipid; and triglyceride homeostasis. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol and nucleus. Is expressed in brain; gut; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in alcoholic liver cirrhosis; carotid stenosis; coronary artery disease; end stage renal disease; and obesity. Orthologous to human FABP2 (fatty acid binding protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 149 figures from 96 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Zhao et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fabp2 | Zhao et al., 2020 | |
| CRISPR2-fabp2 | Wu et al., 2023 | |
| CRISPR3-fabp2 | Wu et al., 2023 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Calycin | Cytosolic fatty-acid binding | Intracellular lipid binding protein | Lipocalin/cytosolic fatty-acid binding domain |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BI88
|
183 | ||||
|
UniProtKB:Q8AX65
|
132 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-4.5fabp2:DsRed) |
|
| 1 | (10) | |
| Tg2(fabp2:DsRed) |
|
| 1 | He et al., 2017 | |
| Tg2(fabp2:GFP) |
|
| 1 | Wei et al., 2023 | |
| Tg(CMV:fabp2-GFP) |
|
| 1 | Zhao et al., 2020 | |
| Tg(fabp2:apoa1a-mCherry) |
|
| 1 | Otis et al., 2019 | |
| Tg(fabp2:CFP-NTR) |
|
| 1 | Wei et al., 2023 | |
| Tg(fabp2:Dendra2-NTR) |
|
| 1 | Wei et al., 2023 | |
| Tg(fabp2:DsRed) |
|
| 2 | (5) | |
| Tg(fabp2:EGFP) |
|
| 1 | (2) | |
| Tg(fabp2:EGFP-acsl3a) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-34B5 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92264 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131431 (1) | 645 nt | ||
| Genomic | GenBank:CU571168 (2) | 111328 nt | ||
| Polypeptide | UniProtKB:A0A8M2BI88 (1) | 183 aa |
- Bao, J., Su, B., Chen, Z., Sun, Z., Peng, J., Zhao, S. (2024) A UTP3-dependent nucleolar translocation pathway facilitates pre-rRNA 5'ETS processing. Nucleic acids research. 52(16):9671-9694
- Han, Y., Sun, K., Yu, S., Qin, Y., Zhang, Z., Luo, J., Hu, H., Dai, L., Cui, M., Jiang, C., Liu, F., Huang, Y., Gao, P., Chen, X., Xin, T., Ren, X., Wu, X., Song, J., Wang, Q., Tang, Z., Chen, J., Zhang, H., Zhang, X., Liu, M., Luo, D. (2024) A Mettl16/m6A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells. The EMBO journal. 43(10):1990-2014
- Li, Q., Wu, L., Wang, G., Zheng, F., Sun, J., Zhang, Y., Li, Z., Li, L., Sun, B. (2024) Inhibitory Effects of Jiuzao Polysaccharides on Alcoholic Fatty Liver Formation in Zebrafish Larvae and Their Regulatory Impact on Intestinal Microbiota. Foods (Basel, Switzerland). 13(2):
- Sam, J., Torregroza, I., Evans, T. (2024) Gata6 functions in zebrafish endoderm to regulate late differentiating arterial pole cardiogenesis. Development (Cambridge, England). 151(17):
- Wang, Z., Liu, Y., Hu, J., You, X., Yang, J., Zhang, Y., Liu, Q., Yang, D. (2024) Tissue-resident trained immunity in hepatocytes protects against septic liver injury in zebrafish. Cell Reports. 43:114324114324
- Zeng, T., Lv, J., Liang, J., Xie, B., Liu, L., Tan, Y., Zhu, J., Jiang, J., Xie, H. (2024) Zebrafish cobll1a regulates lipid homeostasis via the RA signaling pathway. Frontiers in cell and developmental biology. 12:13813621381362
- Dasgupta, S., La Du, J.K., Garcia, G.R., Li, S., Tomono-Duval, K., Rericha, Y., Huang, L., Tanguay, R.L. (2023) A CRISPR-Cas9 mutation in sox9b long intergenic noncoding RNA (slincR) affects zebrafish development, behavior, and regeneration. Toxicological sciences : an official journal of the Society of Toxicology. 194(2):153-166
- Deng, Y., Han, X., Chen, H., Zhao, C., Chen, Y., Zhou, J., de The, H., Zhu, J., Yuan, H. (2023) Ypel5 regulates liver development and function in zebrafish. Journal of molecular cell biology. 15(3):
- El Maï, M., Bird, M., Allouche, A., Targen, S., Şerifoğlu, N., Lopes-Bastos, B., Guigonis, J.M., Kang, D., Pourcher, T., Yue, J.X., Ferreira, M.G. (2023) Gut-specific telomerase expression counteracts systemic aging in telomerase-deficient zebrafish. Nature aging. 3(5):567-584
- He, Y., Wang, Y., Zhu, Y., Lo, L.J. (2023) Loss-of-function of zebrafish cdt1 causes retarded body growth and underdeveloped gonads resembling human Meier-Gorlin syndrome. Journal of Zhejiang University. Science. B. 24:103710461037-1046
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