Gene
gsk3ba
- ID
- ZDB-GENE-990714-4
- Name
- glycogen synthase kinase 3 beta, genome duplicate a
- Symbol
- gsk3ba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable beta-catenin binding activity. Acts upstream of or within angiogenesis; heart jogging; and heart looping. Predicted to be located in plasma membrane. Predicted to be part of beta-catenin destruction complex. Predicted to be active in several cellular components, including axon; cytosol; and glutamatergic synapse. Is expressed in liver; ovary; and testis. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 2 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| f136jy | Allele with one deletion | Unknown | Unknown | CRISPR | |
| f137jy | Allele with one insertion | Unknown | Unknown | CRISPR | |
| la029640Tg | Transgenic insertion | Unknown | Unknown | DNA |
1 - 3 of 3
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-gsk3ba | (3) | |
| MO1-gsk3ba | N/A | (6) |
| MO2-gsk3ba | N/A | Kuo et al., 2014 |
| TALEN1-gsk3ba | (2) |
1 - 4 of 4
Show
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR039192 | Glycogen synthase kinase 3, catalytic domain |
| Family | IPR050591 | Glycogen Synthase Kinase-3 |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | Glycogen Synthase Kinase-3 | Glycogen synthase kinase 3, catalytic domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q9YH60 | InterPro | 421 | ||||||
| UniProtKB:A0A8M3AVR7 | InterPro | 425 |
1 - 2 of 2
Interactions and Pathways
Plasmids
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-32O22 | ZFIN Curated Data | |
| Encodes | EST | fb68h05 | ||
| Encodes | EST | fk80d11 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194027 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131381 (1) | 2624 nt | ||
| Genomic | GenBank:CR759880 (1) | 183450 nt | ||
| Polypeptide | UniProtKB:A0A8M3AVR7 (1) | 425 aa |
- Angom, R.S., Joshi, A., Patowary, A., Sivadas, A., Ramasamy, S., K V, S., Kaushik, K., Sabharwal, A., Lalwani, M.K., K, S., Singh, N., Scaria, V., Sivasubbu, S. (2024) Forward genetic screen using a gene-breaking trap approach identifies a novel role of grin2bb-associated RNA transcript (grin2bbART) in zebrafish heart function. Frontiers in cell and developmental biology. 12:13392921339292
- Bowley, G., Irving, S., Hoefer, I., Wilkinson, R., Pasterkamp, G., Darwish, H.M.S., White, S., Francis, S.E., Chico, T., Noel, E., Serbanovic-Canic, J., Evans, P.C. (2024) Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation. Scientific Reports. 14:3013030130
- Chen, J., Ji, X., Gao, J., Huang, J., Ren, J. (2024) gys1 regulates maternal glycogen reserve essential for embryonic development in zebrafish. Heliyon. 10:e31149e31149
- Karimi, Z., Zarifkar, A., Mirzaei, E., Dianatpour, M., Dara, M., Aligholi, H. (2024) Therapeutic effects of nanosilibinin in valproic acid-zebrafish model of autism spectrum disorder: Focusing on Wnt signaling pathway and autism spectrum disorder-related cytokines. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 84(5):454-468
- Chen, X., Liu, F., Chen, K., Wang, Y., Yin, A., Kang, X., Yang, S., Zhao, H., Dong, S., Li, Y., Chen, J., Wu, Y. (2022) TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration. CNS neuroscience & therapeutics. 28(12):2076-2089
- Fu, S., Tan, R., Feng, Y., Yu, P., Mo, Y., Xiao, W., Wang, S., Zhang, J. (2022) N-methyl-N-nitrosourea induces zebrafish anomalous angiogenesis through Wnt/β-catenin pathway. Ecotoxicology and environmental safety. 239:113674
- Kahsay, A., Rodriguez-Marquez, E., López-Pérez, A., Hörnblad, A., von Hofsten, J. (2022) Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models. Scientific Reports. 12:17149
- Li, A., Gu, Y., Zhang, X., Yu, H., Liu, D., Pang, Q. (2022) Betaine Regulates the Production of Reactive Oxygen Species Through Wnt10b Signaling in the Liver of Zebrafish. Frontiers in Physiology. 13:877178
- Li, Y., Wang, C., Zhang, L., Chen, B., Mo, Y., Zhang, J. (2022) Claudin-5a is essential for the functional formation of both zebrafish blood-brain barrier and blood-cerebrospinal fluid barrier. Fluids and barriers of the CNS. 19:40
- Xu, Y., Liu, J., Tian, Y., Wang, Z., Song, Z., Li, K., Zhang, S., Zhao, H. (2022) Wnt/β-Catenin Signaling Pathway Is Strongly Implicated in Cadmium-Induced Developmental Neurotoxicity and Neuroinflammation: Clues from Zebrafish Neurobehavior and In Vivo Neuroimaging. International Journal of Molecular Sciences. 23(19):
1 - 10 of 65
Show