Gene
dkk1b
- ID
- ZDB-GENE-990708-5
- Name
- dickkopf WNT signaling pathway inhibitor 1b
- Symbol
- dkk1b Nomenclature History
- Previous Names
-
- dkk1
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable co-receptor binding activity and receptor antagonist activity. Involved in endocardial cushion development and heart valve development. Acts upstream of or within several processes, including hepaticobiliary system development; negative regulation of canonical Wnt signaling pathway; and sensory epithelium regeneration. Located in cytoplasm and extracellular region. Is expressed in several structures, including embryonic structure; median fin fold; mesoderm; pharyngeal arch; and sensory system. Human ortholog(s) of this gene implicated in anodontia. Orthologous to human DKK1 (dickkopf WNT signaling pathway inhibitor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 66 figures from 54 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9337 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16096 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19025 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27882 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa27883 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR006796 | Dickkopf, N-terminal cysteine-rich |
| Domain | IPR047304 | Dickkopf-related protein 1, second cysteine-rich domain |
| Domain | IPR048499 | Dickkopf-related protein 1/2/4, C-terminal subdomain 2 |
| Domain | IPR048500 | Dickkopf-related protein 1/2/4, C-terminal subdomain 1 |
| Family | IPR039863 | Dickkopf related protein 1-4 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Dickkopf, N-terminal cysteine-rich | Dickkopf-related protein 1/2/4, C-terminal subdomain 1 | Dickkopf-related protein 1/2/4, C-terminal subdomain 2 | Dickkopf related protein 1-4 | Dickkopf-related protein 1, second cysteine-rich domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q9PWH3 | InterPro | 240 | |||||
| UniProtKB:Q9W6D9 | InterPro | 241 |
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Interactions and Pathways
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:dkk1b-GFP) |
|
| 1 | (112) | |
| Tg2(hsp70l:dkk1b-GFP) |
|
| 1 | (3) | |
| TgBAC(dkk1b:EGFP) |
|
| 1 | (3) | |
| Tg(hsp70l:dkk1b-FLAG) |
|
| 1 | (2) | |
| Tg(hsp70l:dkk1b-mCherry) |
|
| 1 | (2) | |
| Tg(TETRE:dkk1b-GFP) |
|
| 1 | (3) | |
| Tg(UAS:dkk1b-UTRnanos3) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31K12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152787 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192261 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131003 (1) | 841 nt | ||
| Genomic | GenBank:CR925795 (1) | 212255 nt | ||
| Polypeptide | UniProtKB:Q9W6D9 (1) | 241 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Miao, D., Ren, J., Jia, Y., Jia, Y., Li, Y., Huang, H., Gao, R. (2024) PAX1 represses canonical Wnt signaling pathway and plays dual roles during endoderm differentiation. Cell communication and signaling : CCS. 22:242242
- Benard, E.L., Küçükaylak, I., Hatzold, J., Berendes, K.U.W., Carney, T.J., Beleggia, F., Hammerschmidt, M. (2023) wnt10a is required for zebrafish median fin fold maintenance and adult unpaired fin metamorphosis. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(6):566-592
- Fleischhauer, L., López-Delgado, A.C., Geurtzen, K., Knopf, F. (2023) Glucocorticoid effects in the regenerating fin reflect tissue homeostasis disturbances in zebrafish by affecting Wnt signaling. Frontiers in endocrinology. 14:11223511122351
- Liu, X., Jones, W.D., Quesnel-Vallières, M., Devadiga, S.A., Lorent, K., Valvezan, A.J., Myers, R.L., Li, N., Lengner, C.J., Barash, Y., Pack, M., Klein, P.S. (2023) The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish. Journal of developmental biology. 11(3):
- Chen, X., Liu, F., Chen, K., Wang, Y., Yin, A., Kang, X., Yang, S., Zhao, H., Dong, S., Li, Y., Chen, J., Wu, Y. (2022) TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration. CNS neuroscience & therapeutics. 28(12):2076-2089
- Fan, C., Ouyang, Y., Yuan, X., Wang, J. (2022) An enhancer trap zebrafish line for lateral line development and regulation of six2b expression. Gene expression patterns : GEP. 43:119231
- Tan, A.L., Mohanty, S., Guo, J., Lekven, A.C., Riley, B.B. (2022) Pax2a, Sp5a and Sp5l act downstream of Fgf and Wnt to coordinate sensory-neural patterning in the inner ear. Developmental Biology. 492:139-153
- Westphal, M., Panza, P., Kastenhuber, E., Wehrle, J., Driever, W. (2022) Wnt/β-catenin signaling promotes neurogenesis in the diencephalospinal dopaminergic system of embryonic zebrafish. Scientific Reports. 12:1030
- Xu, Y., Liu, J., Tian, Y., Wang, Z., Song, Z., Li, K., Zhang, S., Zhao, H. (2022) Wnt/β-Catenin Signaling Pathway Is Strongly Implicated in Cadmium-Induced Developmental Neurotoxicity and Neuroinflammation: Clues from Zebrafish Neurobehavior and In Vivo Neuroimaging. International Journal of Molecular Sciences. 23(19):
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