Gene
tbx16
- ID
- ZDB-GENE-990615-5
- Name
- T-box transcription factor 16
- Symbol
- tbx16 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including convergent extension; gastrulation; and tube morphogenesis. Located in chromatin and nucleus. Is expressed in several structures, including forerunner cell group; germ ring; mesoderm; presumptive mesoderm; and spinal cord.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 93 figures from 66 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb103 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 61 figures from 34 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b104 | Allele with one delins | Unknown | Premature Stop | spontaneous | |
| hi2109Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| hi3714Tg | Transgenic insertion | Intron 1 | Unknown | DNA | |
| ihb798 | Allele with one delins | Exon 5 | Unknown | CRISPR | |
| ihb799 | Allele with one insertion | Exon 5 | Unknown | CRISPR | |
| kt378b | Allele with one point mutation | Acceptor Splice Site of Intron 1 | Unknown | ENU | |
| la016429Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026643Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la026644Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029508Tg | Transgenic insertion | Unknown | Unknown | DNA |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Family | IPR001699 | T-box transcription factor |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
| Homologous_superfamily | IPR036960 | T-box superfamily |
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Domain Details Per Protein
| Protein | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor, DNA-binding domain | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|
|
UniProtKB:O93389
|
470 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-1.2tbx16:TagRFP) |
|
| 1 | Bouldin et al., 2015 | |
| Tg(-1.2tbx16:TagRFP,cryaa:GFP) |
|
| 1 | Bouldin et al., 2015 | |
| Tg2(hsp70l:tbx16-2A-NLS-KikGR) |
| 1 | Bouldin et al., 2015 | ||
| Tg(HSE:tbx16-MYC,EGFP) |
|
| 1 | (3) | |
| Tg(hsp70l:tbx16-2A-NLS-KikGR) |
| 1 | Goto et al., 2017 | ||
| Tg(hsp70l:tbx16-ENR-2A-NLS-KikGR) |
| 1 | Bouldin et al., 2015 | ||
| Tg(tbx16:EGFP) |
|
| 4 | (8) | |
| Tg(tbx16:mRFP) |
|
| 1 | Manning et al., 2015 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-313L22 | ZFIN Curated Data | |
| Encodes | EST | cb103 | Thisse et al., 2001 | |
| Encodes | EST | fa17g07 | ZFIN Curated Data | |
| Encodes | EST | ibd2185 | ||
| Encodes | STS | chunp30288 | ||
| Encodes | cDNA | MGC:109817 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193075 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131058 (1) | 2561 nt | ||
| Genomic | GenBank:CU459194 (2) | 101559 nt | ||
| Polypeptide | UniProtKB:O93389 (1) | 470 aa |
No data available
- Koparir, A., Lekszas, C., Keseroglu, K., Rose, T., Rappl, L., Rad, A., Maroofian, R., Narendran, N., Hasanzadeh, A., Karimiani, E.G., Boschann, F., Kornak, U., Klopocki, E., Özbudak, E.M., Vona, B., Haaf, T., Liedtke, D. (2024) Zebrafish as a model to investigate a biallelic gain-of-function variant in MSGN1, associated with a novel skeletal dysplasia syndrome. Human genomics. 18:2323
- Labudina, A.A., Meier, M., Gimenez, G., Tatarakis, D., Ketharnathan, S., Mackie, B., Schilling, T.F., Antony, J., Horsfield, J.A. (2024) Cohesin composition and dosage independently affect early development in zebrafish. Development (Cambridge, England). 151(15):
- Utsumi, H., Yabe, T., Koshida, S., Yamashita, A., Takada, S. (2024) Deficiency of mastl, a mitotic regulator, results in cell detachment from developing tissues of zebrafish embryos. Frontiers in cell and developmental biology. 12:13756551375655
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Saunders, L.M., Srivatsan, S.R., Duran, M., Dorrity, M.W., Ewing, B., Linbo, T.H., Shendure, J., Raible, D.W., Moens, C.B., Kimelman, D., Trapnell, C. (2023) Embryo-scale reverse genetics at single-cell resolution. Nature. 623(7988):782-791
- Yuikawa, T., Sato, T., Ikeda, M., Tsuruoka, M., Yasuda, K., Sato, Y., Nasu, K., Yamasu, K. (2023) Elongation of the developing spinal cord is driven by Oct4-type transcription factor-mediated regulation of retinoic acid signaling in zebrafish embryos. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(4):404-422
- Economou, A.D., Guglielmi, L., East, P., Hill, C.S. (2022) Nodal signaling establishes a competency window for stochastic cell fate switching. Developmental Cell. 57:26042622.e52604-2622.e5
- Germano, G., Porazzi, P., Felix, C. (2022) Leukemia-associated transcription factor mllt3 is important for primitive erythroid development in zebrafish embryogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(10):1728-1740
- Liu, S., Wang, L., Chen, K., Yang, H., Ling, M., Wu, L., Zhou, X., Ma, G., Bai, L. (2022) Combined effects of S-metolachlor and benoxacor on embryo development in zebrafish (Danio rerio). Ecotoxicology and environmental safety. 238:113565
- Pattanayak, S., Sarode, B.R., Deiters, A., Chen, J.K. (2022) Bicyclic Caged Morpholino Oligonucleotides for Optical Gene Silencing. Chembiochem : a European journal of chemical biology. 23(21):e202200374
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