Gene
fgf8a
- ID
- ZDB-GENE-990415-72
- Name
- fibroblast growth factor 8a
- Symbol
- fgf8a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in positive regulation of somitomeric trunk muscle development. Acts upstream of or within several processes, including embryonic organ development; heart development; and nervous system development. Located in extracellular space and lysosome. Is expressed in several structures, including germ ring; head; mesoderm; nervous system; and neural keel. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Orthologous to human FGF8 (fibroblast growth factor 8).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 351 figures from 273 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb110 (100 images)
Wild Type Expression Summary
- All Phenotype Data
- 72 figures from 45 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fgf8a_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| la012336Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa2694 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| ti282a | Allele with one point mutation | Donor Splice Site of Intron 3 | Splice Site, Exon Loss of Exon 3, Premature Stop | ENU | |
| tud52Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| tud121Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| x15 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 6 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 6 with or without anosmia | 612702 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytokine IL1/FGF | Fibroblast growth factor family |
|---|---|---|---|---|
| UniProtKB:O57341 | InterPro | 210 | ||
| UniProtKB:A0AB32TYW9 | InterPro | 223 |
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Interactions and Pathways
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(hsp70l:fgf8a) |
|
| 1 | (20) | |
| Tg(hsp70l:fgf8a) |
|
| 1 | (12) | |
| Tg1(fgf8a:EGFP) |
|
| 1 | (3) | |
| Tg1(fgf8a:GFP) |
|
| 1 | (3) | |
| Tg2(fgf8a:EGFP) |
|
| 2 | (3) | |
| Tg2(fgf8a:GFP) |
|
| 1 | (2) | |
| Tg3(fgf8a:GFP) |
|
| 1 | (3) | |
| Tg4(fgf8a:GFP) |
|
| 1 | (3) | |
| Tg5(fgf8a:GFP) |
|
| 1 | (3) | |
| Tg6(fgf8a:GFP) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-194I8 | ZFIN Curated Data | |
| Encodes | EST | cb110 | Thisse et al., 2001 | |
| Encodes | EST | fb73a06 | ZFIN Curated Data | |
| Encodes | EST | ibd5031 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:101652 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192193 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131281 (1) | 2146 nt | ||
| Genomic | GenBank:CR762431 (1) | 96564 nt | ||
| Polypeptide | UniProtKB:A0AB32TYW9 (1) | 223 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Chowdhury, G., Umeda, K., Ohyanagi, T., Nasu, K., Yamasu, K. (2024) Involvement of nr2f genes in brain regionalization and eye development during early zebrafish development. Development, growth & differentiation. 66(2):145-160
- Jędrychowska, J., Vardanyan, V., Wieczor, M., Marciniak, A., Czub, J., Amini, R., Jain, R., Shen, H., Choi, H., Kuznicki, J., Korzh, V. (2024) Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development. Developmental Biology. 513:50-62
- Jiang, X., Zhao, K., Sun, Y., Song, X., Yi, C., Xiong, T., Wang, S., Yu, Y., Chen, X., Liu, R., Yan, X., Antos, C.L. (2024) The scale of zebrafish pectoral fin buds is determined by intercellular K+ levels and consequent Ca2+-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b. PLoS Biology. 22:e3002565e3002565
- Jin, S., Choe, C.P. (2024) A Potential Role of fgf4, fgf24, and fgf17 in Pharyngeal Pouch Formation in Zebrafish. Development & reproduction. 28:556555-65
- Maekawa, M., Saito, S., Isobe, D., Takemoto, K., Miura, Y., Dobashi, Y., Yamasu, K. (2024) The Oct4-related PouV gene, pou5f3, mediates isthmus development in zebrafish by directly and dynamically regulating pax2a. Cells & development. 179:203933
- Umeda, K., Tanaka, K., Chowdhury, G., Nasu, K., Kuroyanagi, Y., Yamasu, K. (2024) Evolutionarily conserved roles of foxg1a in the developing subpallium of zebrafish embryos. Development, growth & differentiation. 66(3):219-234
- Zhao, S., Wang, C., Luo, H., Li, F., Wang, Q., Xu, J., Huang, Z., Liu, W., Zhang, W. (2024) A role for Retinoblastoma 1 in hindbrain morphogenesis by regulating GBX family. Journal of genetics and genomics = Yi chuan xue bao. 51(9):900-910
- Bulk, J., Kyrychenko, V., Rensinghoff, P.M., Ghaderi Ardekani, Z., Heermann, S. (2023) Holoprosencephaly with a Special Form of Anophthalmia Result from Experimental Induction of bmp4, Oversaturating BMP Antagonists in Zebrafish. International Journal of Molecular Sciences. 24(9):
- Cudak, N., López-Delgado, A.C., Keil, S., Knopf, F. (2023) Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene expression patterns : GEP. 48:119307
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