Gene
pparab
- ID
- ZDB-GENE-990415-211
- Name
- peroxisome proliferator-activated receptor alpha b
- Symbol
- pparab Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and nuclear receptor activity. Acts upstream of or within cellular response to cold and response to activity. Predicted to be active in nucleus. Is expressed in several structures, including adipose tissue; digestive system; female organism; nervous system; and spinal cord neural tube. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 29 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- dq017618 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Li et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ecn4 | Allele with one deletion | Unknown | Premature Stop | CRISPR |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR003074 | Peroxisome proliferator-activated receptor |
| Family | IPR003076 | Peroxisome proliferator-activated receptor alpha |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A6XMH7 | InterPro | 459 | ||||||||
| UniProtKB:K7DY57 | InterPro | 459 | ||||||||
| UniProtKB:A0AB32TJ03 | InterPro | 381 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pparab-201
(1)
|
Ensembl | 1,590 nt | ||
| mRNA |
pparab-202
(1)
|
Ensembl | 1,418 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218P2 | ||
| Encodes | EST | dq017618 | Bertrand et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001102567 (1) | 1380 nt | ||
| Genomic | GenBank:CR354430 (1) | 197231 nt | ||
| Polypeptide | UniProtKB:A6XMH7 (1) | 459 aa |
- Liu, N., Zhang, P., Xue, M., Zhang, M., Huang, Z., Xu, C., Meng, Y., Fan, Y., Liu, W., Zhang, F., Chen, P., Zhou, Y. (2024) Hypolipidemic Effect of Rice Bran Oil Extract Tocotrienol in High-Fat Diet-Induced Hyperlipidemia Zebrafish (Danio Rerio) Induced by High-Fat Diet. International Journal of Molecular Sciences. 25(5):
- Raas, Q., Wood, A., Stevenson, T.J., Swartwood, S., Liu, S., Kannan, R.M., Kannan, S., Bonkowsky, J.L. (2024) Generation and characterization of a zebrafish gain-of-function ACOX1 Mitchell disease model. Frontiers in pediatrics. 12:13268861326886
- Wang, Z., Liu, Y., Hu, J., You, X., Yang, J., Zhang, Y., Liu, Q., Yang, D. (2024) Tissue-resident trained immunity in hepatocytes protects against septic liver injury in zebrafish. Cell Reports. 43:114324114324
- Zang, X., Wang, Y., Han, C., Cui, L., Liu, H., Tian, S., Liu, K., Li, P., Sun, C., Xia, Q., Zhang, Y. (2024) 2-Acetamidophenol (2-AAP) Suppresses the Progression of Atherosclerosis by Alleviating Hyperlipidemia and Attenuating the Ferroptosis Pathway. Marine drugs. 22(11):
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Mi, X., Song, Y., Deng, C., Yan, J., Li, Z., Li, Y., Zheng, J., Yang, W., Gong, L., Shi, J. (2023) Stimulation of liver fibrosis by N2 neutrophils in Wilson's disease. Cellular and molecular gastroenterology and hepatology. 16(5):657-684
- Xi, L., Zhai, G., Liu, Y., Gong, Y., Lu, Q., Zhang, Z., Liu, H., Jin, J., Zhu, X., Yin, Z., Xie, S., Han, D. (2023) Attenuated glucose uptake promotes catabolic metabolism through activated AMPK signaling and impaired insulin signaling in zebrafish. Frontiers in nutrition. 10:11872831187283
- Zhang, Z.F., Song, T.T., Chen, J.F., Lv, G.Y. (2023) Recovery of a hypolipidemic polysaccharide from artificially cultivated Sanghuangporus vaninii with an effective method. Frontiers in nutrition. 9:10955561095556
- Zhong, S., Chen, L., Li, X., Wang, X., Ji, G., Sun, C., Liu, Z. (2023) Bmp8a deletion leads to obesity through regulation of lipid metabolism and adipocyte differentiation. Communications biology. 6:824824
- Zou, Y.Y., Tang, X.B., Chen, Z.L., Liu, B., Zheng, L., Song, M.Y., Xiao, Q., Zhou, Z.Q., Peng, X.Y., Tang, C.F. (2023) Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish. Frontiers in endocrinology. 14:11624851162485
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