Gene
apoa1a
- ID
- ZDB-GENE-990415-14
- Name
- apolipoprotein A-Ia
- Symbol
- apoa1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable several functions, including cholesterol transfer activity; high-density lipoprotein particle binding activity; and phosphatidylcholine-sterol O-acyltransferase activator activity. Predicted to be involved in several processes, including acylglycerol homeostasis; cholesterol efflux; and phospholipid efflux. Predicted to act upstream of or within cholesterol biosynthetic process and cholesterol transport. Located in extracellular region. Is expressed in digestive system; ovary; ventral telencephalon; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial hypercholesterolemia; hypolipoproteinemia (multiple); metabolic dysfunction-associated steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb49 (2 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary hypoalphalipoproteinemia 2 | Alliance | Hypoalphalipoproteinemia, primary, 2 | 618463 |
| Amyloidosis, hereditary systemic 3 | 620657 | ||
| Hypoalphalipoproteinemia, primary, 2, intermediate | 619836 |
1 - 3 of 3
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Apolipoprotein A1/A4/E | Apolipoprotein A/E |
|---|---|---|---|---|
| UniProtKB:O42363 | InterPro | 262 |
1 - 1 of 1
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
apoa1a-201
(1)
|
Ensembl | 974 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids