Gene

lpla

ID
ZDB-GENE-990415-139
Name
lipoprotein lipase a
Symbol
lpla Nomenclature History
Previous Names
  • lpl
  • fb62e04
  • fc49b03
  • wu:fb62e04 (1)
  • wu:fc49b03 (1)
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to enable apolipoprotein binding activity; lipoprotein lipase activity; and phospholipase A1 activity. Acts upstream of or within definitive hemopoiesis and response to (R)-carnitine. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of chylomicron and very-low-density lipoprotein particle. Predicted to be active in extracellular space. Is expressed in several structures, including digestive system; head; immature eye; midbrain; and ovary. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Orthologous to human LPL (lipoprotein lipase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
48 figures from 31 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from Liu et al., 2018
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
sa24119Allele with one point mutationUnknownSplice SiteENU
Zebrafish International Resource Center (ZIRC) (order this)
European Zebrafish Resource Center (EZRC) (order this)
sd51Allele with one delinsExon 4Frameshift, Premature StopCRISPR
1 - 2 of 2
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Sequence Targeting Reagents
Human Disease
Associated With lpla Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial combined hyperlipidemia Alliance Combined hyperlipidemia, familial 144250
familial lipoprotein lipase deficiency Alliance Lipoprotein lipase deficiency 238600
familial lipoprotein lipase deficiency Alliance [High density lipoprotein cholesterol level QTL 11] 238600
1 - 3 of 3
Associated With lpla Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001024 PLAT/LH2 domain
Domain IPR013818 Lipase
Domain IPR033906 Lipase, N-terminal
Family IPR000734 Triacylglycerol lipase family
Family IPR002330 Lipoprotein lipase
1 - 5 of 8 Show all
Domain Details Per Protein
Protein Additional Resources Length Alpha/Beta hydrolase fold Lipase Lipase, LIPH-type Lipase, N-terminal Lipoprotein lipase PLAT/LH2 domain PLAT/LH2 domain superfamily Triacylglycerol lipase family
UniProtKB:Q6P2U2 InterPro 511
1 - 1 of 1
Transcripts
Genome Browsers
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA lpla-201 (1)
Ensembl
Ensembl 3,322 nt
ZFIN BLAST
1 - 1 of 1
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations
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