Gene
wnt5b
- ID
- ZDB-GENE-980526-87
- Name
- wingless-type MMTV integration site family, member 5b
- Symbol
- wnt5b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Enables signaling receptor binding activity. Involved in muscle cell differentiation; positive regulation of convergent extension involved in gastrulation; and positive regulation of non-canonical Wnt signaling pathway. Acts upstream of or within with a positive effect on midbrain-hindbrain boundary morphogenesis. Acts upstream of or within several processes, including convergent extension; skeletal system development; and vasculature development. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; cranial cartilage; fin; germ ring; and mesoderm. Orthologous to human WNT5B (Wnt family member 5B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 57 figures from 45 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu891 (17 images)
Wild Type Expression Summary
- All Phenotype Data
- 80 figures from 37 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hi1780bTg | Transgenic insertion | Exon 4 | Unknown | DNA | |
| hi2735bTg | Transgenic insertion | Intron 4 | Unknown | DNA | |
| la015530Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024747Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029041Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa33385 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45164 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sk13 | Allele with one point mutation | Unknown | Unknown | ENU | |
| ta98 | Allele with one point mutation | Unknown | Missense | ENU | |
| tc271b | unknown | Unknown | Unknown | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Wnt | Wnt, C-terminal domain | Wnt protein, conserved site |
|---|---|---|---|---|---|
| UniProtKB:Q92050 | InterPro | 363 | |||
| UniProtKB:A0A8M6Z5V6 | InterPro | 380 | |||
| UniProtKB:B3DI33 | InterPro | 363 |
Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:wnt5b-GFP) |
|
| 1 | (9) | |
| Tg(hsp70l:wnt5b-IRES-Tomato,cryaa:EGFP) |
| 1 | Jussila et al., 2022 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-211C7 | ZFIN Curated Data | |
| Contained in | BAC | CH211-281K12 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-85M15 | ZFIN Curated Data | |
| Encodes | EST | eu891 | Thisse et al., 2005 | |
| Encodes | EST | fk85g06 | ||
| Encodes | EST | ibd5111 | ZFIN Curated Data | |
| Encodes | STS | chunp6928 | ||
| Encodes | cDNA | MGC:194419 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194422 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_130937 (1) | 4807 nt | ||
| Genomic | GenBank:BX649324 (1) | 218137 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z5V6 (1) | 380 aa |
- Dennhag, N., Kahsay, A., Nissen, I., Nord, H., Chermenina, M., Liu, J., Arner, A., Liu, J.X., Backman, L.J., Remeseiro, S., von Hofsten, J., Pedrosa Domellöf, F. (2024) fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles. Nature communications. 15:19501950
- Cao, S., Dong, Z., Dong, X., Jia, W., Zhou, F., Zhao, Q. (2023) Zebrafish sox2 Is Required for the Swim Bladder Inflation by Controlling the Swim-Up Behavior. Zebrafish. 20:101810-18
- Dranow, D.B., Le Pabic, P., Schilling, T.F. (2023) The non-canonical Wnt receptor Ror2 is required for cartilage cell polarity and morphogenesis of the craniofacial skeleton in zebrafish. Development (Cambridge, England). 150(8):
- Emmerich, K., Walker, S.L., Wang, G., White, D.T., Ceisel, A., Wang, F., Teng, Y., Chunawala, Z., Graziano, G., Nimmagadda, S., Saxena, M.T., Qian, J., Mumm, J.S. (2023) Transcriptomic comparison of two selective retinal cell ablation paradigms in zebrafish reveals shared and cell-specific regenerative responses. PLoS Genetics. 19:e1010905e1010905
- Yao, J., Cai, Y., Chen, Z., Wang, X., Lai, X., Pan, L., Li, Y., Wang, S. (2023) DExH/D RNA helicase 15 regulates zebrafish intestinal development through the Wnt signaling pathway. Genomics. 115(2):110578
- Yu, E.P.Y., Saxena, V., Perin, S., Ekker, M. (2023) Loss of dlx5a/dlx6a Locus Alters Non-Canonical Wnt Signaling and Meckel's Cartilage Morphology. Biomolecules. 13(9):
- Blackwell, D.L., Fraser, S.D., Caluseriu, O., Vivori, C., Tyndall, A.V., Lamont, R.E., Parboosingh, J.S., Innes, A.M., Bernier, F.P., Childs, S.J. (2022) Hnrnpul1 controls transcription, splicing, and modulates skeletal and limb development in vivo. G3 (Bethesda). 12(5):
- Jussila, M., Boswell, C.W., Griffiths, N.W., Pumputis, P.G., Ciruna, B. (2022) Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2. Nature communications. 13:5598
- Martin, M., Vermeiren, S., Bostaille, N., Eubelen, M., Spitzer, D., Vermeersch, M., Profaci, C.P., Pozuelo, E., Toussay, X., Raman-Nair, J., Tebabi, P., America, M., De Groote, A., Sanderson, L.E., Cabochette, P., Germano, R.F.V., Torres, D., Boutry, S., de Kerchove d'Exaerde, A., Bellefroid, E.J., Phoenix, T.N., Devraj, K., Lacoste, B., Daneman, R., Liebner, S., Vanhollebeke, B. (2022) Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders. Science (New York, N.Y.). 375:eabm4459
- Saraswathy, V.M., Kurup, A.J., Sharma, P., Polès, S., Poulain, M., Fürthauer, M. (2022) The E3 Ubiquitin Ligase Mindbomb1 controls planar cell polarity-dependent convergent extension movements during zebrafish gastrulation. eLIFE. 11:
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