Gene
tbxta
- ID
- ZDB-GENE-980526-437
- Name
- T-box transcription factor Ta
- Symbol
- tbxta Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Enables transcription cis-regulatory region binding activity. Acts upstream of or within several processes, including convergent extension; notochord development; and regionalization. Located in chromatin and nucleus. Is expressed in several structures, including blastoderm; germ ring; mesoderm; presumptive structure; and tail bud. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human TBXT (T-box transcription factor T).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 554 figures from 387 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb240 (18 images)
Wild Type Expression Summary
- All Phenotype Data
- 52 figures from 35 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| b160 | Allele with one delins | Unknown | Unknown | g-rays | |
| b195 | Allele with one insertion | Unknown | Unknown | spontaneous | |
| b459 | unknown | Unknown | Unknown | not specified | |
| b487 | unknown | Unknown | Unknown | not specified | |
| kt338 | unknown | Unknown | Unknown | not specified | |
| kt501a | unknown | Unknown | Unknown | not specified | |
| kt633 | unknown | Unknown | Unknown | not specified | |
| m147 | unknown | Unknown | Unknown | ENU | |
| m550 | unknown | Unknown | Unknown | ENU | |
| sa13983 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018186 | Transcription factor, T-box, conserved site |
| Domain | IPR046360 | T-box transcription factor, DNA-binding domain |
| Family | IPR001699 | T-box transcription factor |
| Family | IPR002070 | Transcription factor, Brachyury |
| Homologous_superfamily | IPR008967 | p53-like transcription factor, DNA-binding domain superfamily |
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Domain Details Per Protein
| Protein | Length | p53-like transcription factor, DNA-binding domain superfamily | T-box superfamily | T-box transcription factor | T-box transcription factor, DNA-binding domain | Transcription factor, Brachyury | Transcription factor, T-box, conserved site |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q07998
|
423 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-1tbxta:CFP) |
|
| 1 | (4) | |
| Tg(HSE:ntla-MYC,EGFP) |
|
| 1 | (5) | |
| TgBAC(tbxta:tbxta-FLAG) |
|
|
| 1 | (2) |
| Tg(ntla:GAL4-VP16) |
|
| 1 | (4) | |
| Tg(tbxta:GFP,cryaa:Venus) |
|
| 1 | Zebrafish Nomenclature Committee | |
| Tg(tbxta:Kaede) |
|
| 1 | (3) | |
| Tg(tbxta:LY-Tomato) |
|
| 1 | (3) | |
| Tg(tbxta:mCherry-2A-Cre) |
|
| 1 | Lin et al., 2019 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-285B23 | ZFIN Curated Data | |
| Encodes | EST | cb240 | Thisse et al., 2001 | |
| Encodes | EST | fc80a01 | ZFIN Curated Data | |
| Encodes | EST | ibd5074 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193897 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:193903 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131162 (1) | 2238 nt | ||
| Genomic | GenBank:CU633985 (2) | 108421 nt | ||
| Polypeptide | UniProtKB:Q07998 (1) | 423 aa |
- Camacho-Macorra, C., Tabanera, N., Sánchez-Bustamante, E., Bovolenta, P., Cardozo, M.J. (2024) Maternal vgll4a regulates zebrafish epiboly through Yap1 activity. Frontiers in cell and developmental biology. 12:13626951362695
- Del Prado, J.A., Ding, Y., Sonneville, J., der Kolk, K.V., Moreno-Mateos, M.A., Málaga-Trillo, E., Spaink, H.P. (2024) Comparing robotic and manual injection methods in zebrafish embryos for high-throughput RNA silencing using CRISPR-RfxCas13d. Biotechniques. 76(5):183-191
- Kai, M., Kondo, M. (2024) Suppression of Pcdh8/paraxial protocadherin is required for efficient neighbor exchange in morphogenetic cell movement during zebrafish notochord formation. Scientific Reports. 14:2569725697
- Koparir, A., Lekszas, C., Keseroglu, K., Rose, T., Rappl, L., Rad, A., Maroofian, R., Narendran, N., Hasanzadeh, A., Karimiani, E.G., Boschann, F., Kornak, U., Klopocki, E., Özbudak, E.M., Vona, B., Haaf, T., Liedtke, D. (2024) Zebrafish as a model to investigate a biallelic gain-of-function variant in MSGN1, associated with a novel skeletal dysplasia syndrome. Human genomics. 18:2323
- Labudina, A.A., Meier, M., Gimenez, G., Tatarakis, D., Ketharnathan, S., Mackie, B., Schilling, T.F., Antony, J., Horsfield, J.A. (2024) Cohesin composition and dosage independently affect early development in zebrafish. Development (Cambridge, England). 151(15):
- Ventura Fernandes, B.H., Junqueira, M.S., MacRae, C., Silveira de Carvalho, L.R. (2024) Standardizing CRISPR-Cas13 knockdown technique to investigate the role of cdh2 gene in pituitary development through growth hormone expression and transcription factors. Frontiers in endocrinology. 15:14666381466638
- Das, U., Kundu, J., Shaw, P., Bose, C., Ghosh, A., Gupta, S., Sarkar, S., Bhadra, J., Sinha, S. (2023) Self-transfecting GMO-PMO chimera targeting Nanog enable gene silencing in vitro and suppresses tumor growth in 4T1 allografts in mouse. Molecular therapy. Nucleic acids. 32:203228203-228
- Harish, R.K., Gupta, M., Zöller, D., Hartmann, H., Gheisari, A., Machate, A., Hans, S., Brand, M. (2023) Real-time monitoring of endogenous Fgf8a gradient attests to its role as a morphogen during zebrafish gastrulation. Development (Cambridge, England). 150(19):
- McLeod, J.J., Rothschild, S.C., Francescatto, L., Kim, H., Tombes, R.M. (2023) Specific CaMKIIs mediate convergent extension cell movements in early zebrafish development. Developmental Dynamics : an official publication of the American Association of Anatomists. 253(4):390-403
- Saunders, L.M., Srivatsan, S.R., Duran, M., Dorrity, M.W., Ewing, B., Linbo, T.H., Shendure, J., Raible, D.W., Moens, C.B., Kimelman, D., Trapnell, C. (2023) Embryo-scale reverse genetics at single-cell resolution. Nature. 623(7988):782-791
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