Gene
wnt8a
- ID
- ZDB-GENE-980526-332
- Name
- wingless-type MMTV integration site family, member 8a
- Symbol
- wnt8a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and frizzled binding activity. Involved in several processes, including axis specification; neural crest cell fate specification; and positive regulation of canonical Wnt signaling pathway. Acts upstream of or within with a positive effect on regulation of cell population proliferation. Acts upstream of or within several processes, including gastrulation; regionalization; and regulation of signal transduction. Is active in apoptotic body and cell surface. Is expressed in several structures, including germ ring; mesoderm; ovary; presumptive paraxial mesoderm; and unfertilized egg. Orthologous to human WNT8A (Wnt family member 8A).
- Genome Resources
- Note
-
Ensembl and NCBI associate this with two separate IDs (NCBI - Gene ID: 30122 and Gene ID: 553976). The two Ensembl gene IDs are associated with the gene.
- Comparative Information
-
- All Expression Data
- 66 figures from 59 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 35 figures from 19 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011030Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la018995Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| nub14 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| nub15 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| nub16 | Allele with one deletion | Unknown | Frameshift, Premature Stop | TALEN | |
| nub17 | Allele with one delins | Unknown | Frameshift, Premature Stop | TALEN | |
| nub18 | Allele with one deletion | Unknown | Unknown | TALEN | |
| nub19 | Allele with multiple variants | Unknown | Unknown | TALEN | |
| nub20 | Allele with multiple variants | Unknown | Unknown | TALEN | |
| nub21 | Allele with multiple variants | Unknown | Unknown | TALEN |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Protein Wnt-8A/8C | Wnt | Wnt-8 protein | Wnt, C-terminal domain | Wnt protein, conserved site | Zinc finger C2H2-type |
|---|---|---|---|---|---|---|---|
|
UniProtKB:P51028
|
359 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:wnt8a-GFP) |
|
| 1 | (52) | |
| Tg1(-2.8wnt8a:EGFP) |
|
| 1 | (2) | |
| Tg1(-2.8wnt8a:EGFP-UTR-wnt8a) |
|
| 1 | (3) | |
| Tg(-1.3wnt8a:EGFP) |
|
| 1 | (2) | |
| Tg(-1.8wnt8a:EGFP) |
|
| 1 | (2) | |
| Tg1(Xla.Eef1a1:EGFP-UTR-wnt8a) |
| 1 | (2) | ||
| Tg2(-2.8wnt8a:EGFP) |
|
| 1 | (2) | |
| Tg2(-2.8wnt8a:EGFP-UTR-wnt8a) |
|
| 1 | (3) | |
| Tg(-2.8wnt8a:EGFP) |
|
| 1 | (2) | |
| Tg2(Xla.Eef1a1:EGFP-UTR-wnt8a) |
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-11C15 | ZFIN Curated Data | |
| Contained in | BAC | CH211-232M8 | ZFIN Curated Data | |
| Encodes | EST | fa20e02 | ||
| Encodes | EST | fe05d07 | ||
| Encodes | cDNA | MGC:66187 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191351 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | GenBank:U10869 (1) | 3022 nt | ||
| Genomic | GenBank:BX927327 | 182779 nt | ||
| Polypeptide | UniProtKB:P51028 (1) | 359 aa |
- Comparative Orthology
- Alliance
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Jiang, R.X., Hu, N., Deng, Y.W., Hu, L.W., Gu, H., Luo, N., Wen, J., Jiang, X.Q. (2024) Potential therapeutic role of spermine via Rac1 in osteoporosis: Insights from zebrafish and mice. Zoological research. 45:367380367-380
- Liao, T., Xu, X., Wu, J., Xie, Y., Yan, J. (2023) Increased expression levels of DLX5 inhibit the development of the nervous system. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 83(8):728-739
- Nair, S., Welch, E.L., Moravec, C.E., Trevena, R.L., Hansen, C.L., Pelegri, F. (2023) The midbody component Prc1-like is required for microtubule reorganization during cytokinesis and dorsal determinant segregation in the early zebrafish embryo. Development (Cambridge, England). 150(4)
- Ott, E., Hoff, S., Indorf, L., Ditengou, F.A., Müller, J., Renschler, G., Lienkamp, S.S., Kramer-Zucker, A., Bergmann, C., Epting, D. (2023) A novel role for the chloride intracellular channel protein Clic5 in ciliary function. Scientific Reports. 13:1764717647
- Saunders, L.M., Srivatsan, S.R., Duran, M., Dorrity, M.W., Ewing, B., Linbo, T.H., Shendure, J., Raible, D.W., Moens, C.B., Kimelman, D., Trapnell, C. (2023) Embryo-scale reverse genetics at single-cell resolution. Nature. 623(7988):782-791
- Yabe, T., Uriu, K., Takada, S. (2023) Ripply suppresses Tbx6 to induce dynamic-to-static conversion in somite segmentation. Nature communications. 14:21152115
- Chen, X., Liu, F., Chen, K., Wang, Y., Yin, A., Kang, X., Yang, S., Zhao, H., Dong, S., Li, Y., Chen, J., Wu, Y. (2022) TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration. CNS neuroscience & therapeutics. 28(12):2076-2089
- Hui, S.P., Sugimoto, K., Sheng, D.Z., Kikuchi, K. (2022) Regulatory T cells regulate blastemal proliferation during zebrafish caudal fin regeneration. Frontiers in immunology. 13:981000
- Liu, Y., Kassack, M.E., McFaul, M.E., Christensen, L.N., Siebert, S., Wyatt, S.R., Kamei, C.N., Horst, S., Arroyo, N., Drummond, I.A., Juliano, C.E., Draper, B.W. (2022) Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary. eLIFE. 11:
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