Gene
fgf3
- ID
- ZDB-GENE-980526-178
- Name
- fibroblast growth factor 3
- Symbol
- fgf3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables fibroblast growth factor receptor binding activity. Acts upstream of with a negative effect on Wnt signaling pathway. Acts upstream of or within with a positive effect on hypothalamus development. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and positive regulation of cell differentiation. Located in extracellular matrix and extracellular space. Is expressed in several structures, including brain; mesoderm; neural rod; pharynx; and sensory system. Orthologous to human FGF3 (fibroblast growth factor 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 145 figures from 108 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 32 figures from 17 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fgf3_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| psi60Tg | Transgenic insertion | Unknown | Unknown | DNA and CRISPR | |
| t21142 | Allele with one point mutation | Unknown | Missense | ENU | |
| t24149 | Allele with one point mutation | Unknown | Missense | ENU | |
| t24152 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| t26212 | Allele with one point mutation | Unknown | Missense | ENU | |
| y323Et | Transgenic insertion | Unknown | Unknown | DNA |
1 - 7 of 7
Show
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fgf3 | (2) | |
| CRISPR2-fgf3 | Reuter et al., 2019 | |
| CRISPR3-fgf3 | Reuter et al., 2019 | |
| MO1-fgf3 | N/A | (29) |
| MO2-fgf3 | N/A | (9) |
| MO3-fgf3 | N/A | (7) |
| MO4-fgf3 | N/A | (6) |
| MO5-fgf3 | N/A | (8) |
| MO6-fgf3 | N/A | Shinya et al., 2001 |
| MO7-fgf3 | N/A | Shinya et al., 2001 |
1 - 10 of 12
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Deafness, congenital with inner ear agenesis, microtia, and microdontia | 610706 |
1 - 1 of 1
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytokine IL1/FGF | Fibroblast growth factor family |
|---|---|---|---|
|
UniProtKB:P48802
|
256 | ||
|
UniProtKB:B3DHR1
|
256 |
1 - 2 of 2
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(hsp70l:fgf3) |
|
| 1 | (6) | |
| TgBAC(fgf3:fgf3-sGFP,cryaa:CFP) |
|
| 1 | Durdu et al., 2014 | |
| Tg(fgf3:Hsa.HIST1H2BJ-mTurquoise2) |
|
| (2) | ||
| Tg(hsp70l:fgf3) |
|
| 1 | (2) | |
| Tg(hsp70l:fgf3-MYC) |
|
| 1 | (12) | |
| Tg(LEXOP:sGFP-fgf3,myl7:EGFP) |
| 1 | Durdu et al., 2014 | ||
| Tg(UAS:fgf3,myl7:EGFP) |
|
| 1 | Xu et al., 2018 |
1 - 7 of 7
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-96B20 | ZFIN Curated Data | |
| Encodes | EST | ibd5006 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194262 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194301 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131291 (1) | 771 nt | ||
| Genomic | GenBank:CU896555 (2) | 153440 nt | ||
| Polypeptide | UniProtKB:B3DHR1 (1) | 256 aa |
- Jędrychowska, J., Vardanyan, V., Wieczor, M., Marciniak, A., Czub, J., Amini, R., Jain, R., Shen, H., Choi, H., Kuznicki, J., Korzh, V. (2024) Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development. Developmental Biology. 513:50-62
- Jin, S., Choe, C.P. (2024) A Potential Role of fgf4, fgf24, and fgf17 in Pharyngeal Pouch Formation in Zebrafish. Development & reproduction. 28:556555-65
- Song, W., Xia, X., Fan, Y., Zhang, B., Chen, X. (2024) Functional and Genetic Analyses Unveil the Implication of CDC27 in Hemifacial Microsomia. International Journal of Molecular Sciences. 25(9):
- Sun, L., Ping, L., Fan, X., Fan, Y., Zhang, B., Chen, X. (2024) amer1 Regulates Zebrafish Craniofacial Development by Interacting with the Wnt/β-Catenin Pathway. International Journal of Molecular Sciences. 25(2):
- Tucker, S.K., Gosul, R., Swartz, M.E., Zhang, S., Eberhart, J.K. (2024) Zebrafish raptor mutation inhibits the activity of mTORC1, inducing craniofacial defects due to autophagy-induced neural crest cell death. Development (Cambridge, England). 151(6):
- Cudak, N., López-Delgado, A.C., Keil, S., Knopf, F. (2023) Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene expression patterns : GEP. 48:119307
- Jackson, A., Lin, S.J., Jones, E.A., Chandler, K.E., Orr, D., Moss, C., Haider, Z., Ryan, G., Holden, S., Harrison, M., Burrows, N., Jones, W.D., Loveless, M., Petree, C., Stewart, H., Low, K., Donnelly, D., Lovell, S., Drosou, K., Genomics England Research Consortium, Solve-RD consortium, Varshney, G.K., Banka, S. (2023) Clinical, genetic, epidemiologic, evolutionary, and functional delineation of TSPEAR-related autosomal recessive ectodermal dysplasia 14. HGG advances. 4:100186100186
- Leino, S.A., Constable, S.C.J., Streit, A., Wilkinson, D.G. (2023) Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain. Development (Cambridge, England). 150(18):
- Yang, S., Xu, X., Yin, Z., Liu, Y., Wang, H., Guo, J., Wang, F., Bao, Y., Zhang, T., Sun, S. (2023) nkx2.3 is responsible for posterior pharyngeal cartilage formation by inhibiting Fgf signaling. Heliyon. 9:e21915e21915
- Gebuijs, L., Wagener, F.A., Zethof, J., Carels, C.E., Von den Hoff, J.W., Metz, J.R. (2022) Targeting fibroblast growth factor receptors causes severe craniofacial malformations in zebrafish larvae. PeerJ. 10:e14338e14338
1 - 10 of 238
Show