Gene
pik3ca
- ID
- ZDB-GENE-130409-1
- Name
- phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
- Symbol
- pik3ca Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity; and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Acts upstream of or within regulation of collateral sprouting in absence of injury. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Predicted to be active in cytoplasm and plasma membrane. Is expressed in eye and male organism. Human ortholog(s) of this gene implicated in several diseases, including CLOVES syndrome; Cowden syndrome 5; breast cancer (multiple); cutaneous Paget's disease; and gastrointestinal system cancer (multiple). Orthologous to human PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Schmidt et al., 2014
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa16936 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa25449 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa35126 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35127 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35128 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45434 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-pik3ca | Xu et al., 2017 | |
| CRISPR2-pik3ca | Xu et al., 2017 | |
| CRISPR3-pik3ca | Xu et al., 2017 | |
| MO1-pik3ca | N/A | Schmidt et al., 2014 |
| MO2-pik3ca | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| breast cancer | Alliance | Breast cancer, somatic | 114480 |
| CLOVES syndrome | Alliance | CLOVE syndrome, somatic | 612918 |
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| Cowden syndrome 5 | Alliance | Cowden syndrome 5 | 615108 |
| epidermal nevus | Alliance | Nevus, epidermal, somatic | 162900 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| Domain | IPR000341 | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain |
| Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| Domain | IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
| Domain | IPR002420 | C2 phosphatidylinositol 3-kinase-type domain |
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Domain Details Per Protein
| Protein | Length | Armadillo-type fold | C2 domain superfamily | C2 phosphatidylinositol 3-kinase-type domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | Phosphatidylinositol 3-kinase, adaptor-binding domain | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain | Phosphatidylinositol kinase | Phosphoinositide 3-kinase, accessory (PIK) domain | Phosphoinositide 3-kinase, accessory (PIK) domain superfamily | Protein kinase-like domain superfamily | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QAD7
|
1069 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pik3ca-201
(1)
|
Ensembl | 3,684 nt | ||
| mRNA |
pik3ca-202
(1)
|
Ensembl | 4,279 nt | ||
| mRNA |
pik3ca-203
(1)
|
Ensembl | 3,989 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-25G11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068224385 (1) | 5277 nt | ||
| Genomic | GenBank:BX548160 (2) | 237930 nt | ||
| Polypeptide | UniProtKB:F1QAD7 (1) | 1069 aa |
- Comparative Orthology
- Alliance
- Zheng, Y.Q., Suo, G.H., Liu, D., Li, H.Y., Wu, Y.J., Ni, H. (2022) Nexmifa Regulates Axon Morphogenesis in Motor Neurons in Zebrafish. Frontiers in molecular neuroscience. 15:848257
- Chen, Z., Zhou, Z., Peng, X., Sun, C., Yang, D., Li, C., Zhu, R., Zhang, P., Zheng, L., Tang, C. (2021) Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart. The journal of physiological sciences : JPS. 71:33
- Mawed, S.A., He, Y., Zhang, J., Mei, J. (2020) Strategy of Hepatic Metabolic Defects Induced by beclin1 Heterozygosity in Adult Zebrafish. International Journal of Molecular Sciences. 21(4):
- Mazumder, A.G., Kumari, S., Singh, D. (2019) Anticonvulsant action of a selective phosphatidylinositol-3-kinase inhibitor LY294002 in pentylenetetrazole-mediated convulsions in zebrafish. Epilepsy Research. 157:106207
- Tanwar, G., Mazumder, A.G., Bhardwaj, V., Kumari, S., Bharti, R., Yamini, ., Singh, D., Das, P., Purohit, R. (2019) Target identification, screening and in vivo evaluation of pyrrolone-fused benzosuberene compounds against human epilepsy using Zebrafish model of pentylenetetrazol-induced seizures. Scientific Reports. 9:7904
- Yang, W.Y., Rao, P.S., Luo, Y.C., Lin, H.K., Huang, S.H., Yang, J.M., Yuh, A.C. (2019) Omics-based Investigation of Diet-induced Obesity Synergized with HBx, Src, and p53 Mutation Accelerating Hepatocarcinogenesis in Zebrafish Model. Cancers. 11(12):
- Zhang, Y.M., Zimmer, M.A., Guardia, T., Callahan, S.J., Mondal, C., Di Martino, J., Takagi, T., Fennell, M., Garippa, R., Campbell, N.R., Bravo-Cordero, J.J., White, R.M. (2018) Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2. Developmental Cell. 45(5):580-594.e7
- Fei, F., Sun, S.Y., Yao, Y.X., Wang, X. (2017) [Generation and phenotype analysis of zebrafish mutations of obesity-related genes lepr and mc4r]. Sheng li xue bao : [Acta physiologica Sinica]. 69:61-69
- Xu, W., Jin, M., Hu, R., Wang, H., Zhang, F., Yuan, S., Cao, Y. (2017) The Joubert Syndrome Protein Inpp5e Controls Ciliogenesis by Regulating Phosphoinositides at the Apical Membrane. Journal of the American Society of Nephrology : JASN. 28(1):118-129
- Yang, B.Y., Zhai, G., Gong, Y.L., Su, J.Z., Peng, X.Y., Shang, G.H., Han, D., Jin, J.Y., Liu, H.K., Du, Z.Y., Yin, Z., Xie, S.Q. (2017) Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. American journal of physiology. Endocrinology and metabolism. 315(1):E38-E51
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