Gene
cyp27a1.2
- ID
- ZDB-GENE-081104-511
- Name
- cytochrome P450, family 27, subfamily A, polypeptide 1, gene 2
- Symbol
- cyp27a1.2 Nomenclature History
- Previous Names
-
- si:dkeyp-68f9.10
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable cholesterol 26-hydroxylase activity and vitamin D3 25-hydroxylase activity. Predicted to be involved in calcitriol biosynthetic process from calciol and cholesterol metabolic process. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrion.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6152 | Allele with one point mutation | Unknown | Missense, Splice Site | ENU | |
| sa14111 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21546 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa27447 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450, families 11 and 27 | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:E9QJ06 | InterPro | 522 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp27a1.2-201
(1)
|
Ensembl | 1,818 nt | ||
| ncRNA |
cyp27a1.2-002
(1)
|
Ensembl | 882 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-68F9 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001333968 (1) | |||
| Genomic | GenBank:BX001051 (1) | 213486 nt | ||
| Polypeptide | UniProtKB:E9QJ06 (1) | 522 aa |
No data available
- Gao, P., Jia, D., Li, P., Huang, Y., Hu, H., Sun, K., Lv, Y., Chen, X., Han, Y., Zhang, Z., Ren, X., Wang, Q., Liu, F., Tang, Z., Liu, M. (2022) Accumulation of Lipid Droplets in a Novel Bietti Crystalline Dystrophy Zebrafish Model With Impaired PPARα Pathway. Investigative ophthalmology & visual science. 63:32
- Singh, M.K., Jayarajan, R., Varshney, S., Upadrasta, S., Singh, A., Yadav, R., Scaria, V., Sengupta, S., Shanmugam, D., Shalimar, ., Sivasubbu, S., Gandotra, S., Sachidanandan, C. (2021) Chronic systemic exposure to IL6 leads to deregulation of glycolysis and fat accumulation in the zebrafish liver. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(5):158905
- Valenzuela, L., Pacheco, S., Rincón, G., Pavez, L., Lam, N., Hernández, A.J., Dantagnan, P., González, F., Jilberto, F., Ravanal, M.C., Ramos, C., Garcia, H., Araneda, C., Ulloa, P.E. (2021) Intestinal Transcriptome Analysis Reveals Enrichment of Genes Associated with Immune and Lipid Mechanisms, Favoring Soybean Meal Tolerance in High-Growth Zebrafish (Danio Rerio). Genes. 12(5):
- Wu, X., Xiong, F., Fang, H., Zhang, J., Chang, M. (2021) Crosstalks between NOD1 and Histone H2A Contribute to Host Defense against Streptococcus agalactiae Infection in Zebrafish. Antibiotics (Basel, Switzerland). 10(7):
- Zhu, Y., Yang, D., Duan, X., Zhang, Y., Chen, D., Gong, Z., Liu, C. (2021) Perfluorooctane Sulfonate Promotes Doxycycline-induced Liver Tumor Progression in Male Krasv12 Transgenic Zebrafish. Environmental research. 196:110962
- Kim, Y.C., Lee, S.R., Jeon, H.J., Kim, K., Kim, M.J., Choi, S.D., Lee, S.E. (2020) Acute toxicities of fluorene, fluorene-1-carboxylic acid, and fluorene-9-carboxylic acid on zebrafish embryos (Danio rerio): Molecular mechanisms of developmental toxicities of fluorene-1-carboxylic acid. Chemosphere. 260:127622
- Lin, C.H., Tsai, I.L., Su, C.H., Tseng, D.Y., and Hwang, P.P. (2011) Reverse Effect of Mammalian Hypocalcemic Cortisol in Fish: Cortisol Stimulates Ca Uptake via Glucocorticoid Receptor-Mediated Vitamin D(3) Metabolism. PLoS One. 6(8):e23689
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