Gene
wnt3
- ID
- ZDB-GENE-081003-1
- Name
- wingless-type MMTV integration site family, member 3
- Symbol
- wnt3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within cloaca development and thalamus development. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including basal plate midbrain region; brain; midbrain hindbrain boundary neural tube; posterior neural tube; and presumptive diencephalon. Human ortholog(s) of this gene implicated in tetraamelia syndrome 1. Orthologous to human WNT3 (Wnt family member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 16 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Baranowska Körberg et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-wnt3 | N/A | (3) |
| MO2-wnt3 | N/A | Teh et al., 2015 |
| MO3-wnt3 | N/A | Teh et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| tetraamelia syndrome 1 | Alliance | ?Tetra-amelia syndrome 1 | 273395 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Wnt | Wnt-3 protein | Wnt, C-terminal domain | Wnt protein, conserved site |
|---|---|---|---|---|---|
|
UniProtKB:B0LK22
|
355 |
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Interactions and Pathways
No data available
Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:wnt3-GFP) |
|
| 1 | (3) | |
| Tg(-4.0wnt3:EGFP) |
|
| 3 | (3) | |
| Tg(-4.0wnt3:fzd1-mApple) |
|
| 1 | (2) | |
| Tg(-4.0wnt3:PLMTmApple) |
|
| 1 | (2) | |
| Tg(-4.0wnt3:wnt3-EGFP) |
|
|
| 3 | (6) |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001114552 (1) | 1499 nt | ||
| Genomic | GenBank:CR388157 (1) | 225145 nt | ||
| Polypeptide | UniProtKB:B0LK22 (1) | 355 aa |
- Kareklas, K., Teles, M.C., Dreosti, E., Oliveira, R.F. (2023) Autism-associated gene shank3 is necessary for social contagion in zebrafish. Molecular autism. 14:2323
- Liu, W., Lin, S., Li, L., Tai, Z., Liu, J.X. (2023) Zebrafish ELL-associated factors Eaf1/2 modulate erythropoiesis via regulating gata1a expression and WNT signaling to facilitate hypoxia tolerance. Cell regeneration (London, England). 12:1010
- Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113
- Dhasmana, D., Veerapathiran, S., Azbazdar, Y., Nelanuthala, A.V.S., Teh, C., Ozhan, G., Wohland, T. (2021) Wnt3 Is Lipidated at Conserved Cysteine and Serine Residues in Zebrafish Neural Tissue. Frontiers in cell and developmental biology. 9:671218
- Lee, H.J., Hou, Y., Chen, Y., Dailey, Z.Z., Riddihough, A., Jang, H.S., Wang, T., Johnson, S.L. (2020) Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility. Genome biology. 21:52
- Lee, Y., Kim, D., Lee, C.J. (2020) Suppressive effects of valproic acid on caudal fin regeneration in adult zebrafish. Animal cells and systems. 24:349-358
- Naderi, M., Salahinejad, A., Attaran, A., Chivers, D.P., Niyogi, S. (2020) Chronic exposure to environmentally relevant concentrations of bisphenol S differentially affects cognitive behaviors in adult female zebrafish. Environmental pollution (Barking, Essex : 1987). 261:114060
- Veerapathiran, S., Teh, C., Zhu, S., Kartigayen, I., Korzh, V., Matsudaira, P.T., Wohland, T. (2020) Wnt3 distribution in the zebrafish brain is determined by expression, diffusion and multiple molecular interactions. eLIFE. 9:
- Zhu, J., Wang, H.T., Chen, Y.R., Yan, L.Y., Han, Y.Y., Liu, L.Y., Cao, Y., Liu, Z.Z., Xu, H.A. (2020) The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish. Neuroscience Bulletin. 36(9):1023-1034
- Azbazdar, Y., Ozalp, O., Sezgin, E., Veerapathiran, S., Duncan, A.L., Sansom, M.S.P., Eggeling, C., Wohland, T., Karaca, E., Ozhan, G. (2019) More Favorable Palmitic Acid Over Palmitoleic Acid Modification of Wnt3 Ensures Its Localization and Activity in Plasma Membrane Domains. Frontiers in cell and developmental biology. 7:281
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