Gene
spred3
- ID
- ZDB-GENE-061207-31
- Name
- sprouty related EVH1 domain containing 3
- Symbol
- spred3 Nomenclature History
- Previous Names
-
- si:ch211-255l12.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable protein kinase binding activity. Predicted to be involved in negative regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within regulation of signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human SPRED3 (sprouty related EVH1 domain containing 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | c-Kit-binding domain | PH-like domain superfamily | SPRE, EVH1 domain | Sprouty | WH1/EVH1 domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PFJ0 | InterPro | 176 | |||||
| UniProtKB:A0A8M1NF21 | InterPro | 380 | |||||
| UniProtKB:A0A8M9P152 | InterPro | 540 | |||||
| UniProtKB:A9UL48 | InterPro | 144 | |||||
| UniProtKB:A0A140LGD0 | InterPro | 508 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
spred3-201
(1)
|
Ensembl | 3,685 nt | ||
| mRNA |
spred3-203
(1)
|
Ensembl | 3,938 nt | ||
| mRNA |
spred3-204
(1)
|
Ensembl | 3,685 nt | ||
| ncRNA |
spred3-002
(1)
|
Ensembl | 753 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-255L12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:175243 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113215 (1) | 3705 nt | ||
| Genomic | GenBank:BX908775 (1) | 82190 nt | ||
| Polypeptide | UniProtKB:A0A8M9P152 (1) | 540 aa |
- Motta, M., Fasano, G., Gredy, S., Brinkmann, J., Bonnard, A.A., Simsek-Kiper, P.O., Gulec, E.Y., Essaddam, L., Utine, G.E., Guarnetti Prandi, I., Venditti, M., Pantaleoni, F., Radio, F.C., Ciolfi, A., Petrini, S., Consoli, F., Vignal, C., Hepbasli, D., Ullrich, M., de Boer, E., Vissers, L.E.L.M., Gritli, S., Rossi, C., De Luca, A., Ben Becher, S., Gelb, B.D., Dallapiccola, B., Lauri, A., Chillemi, G., Schuh, K., Cavé, H., Zenker, M., Tartaglia, M. (2021) SPRED2 loss-of-function causes a recessive Noonan syndrome-like phenotype. American journal of human genetics. 108(11):2112-2129
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Stulberg, M.J., Lin, A., Zhao, H., and Holley, S.A. (2012) Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud. Developmental Biology. 369(2):298-307
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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