Gene
rps6ka1
- ID
- ZDB-GENE-060929-516
- Name
- ribosomal protein S6 kinase a, polypeptide 1
- Symbol
- rps6ka1 Nomenclature History
- Previous Names
-
- wu:fc56h07
- zgc:152654
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in alcohol-related birth defects. Orthologous to human RPS6KA1 (ribosomal protein S6 kinase A1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|
| UniProtKB:Q08CV8 | InterPro | 310 | |||
| UniProtKB:A0AB32T7I9 | InterPro | 758 | |||
| UniProtKB:A0AB32T7P8 | InterPro | 755 | |||
| UniProtKB:A0AB32T915 | InterPro | 740 | |||
| UniProtKB:A0AB32TB58 | InterPro | 763 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
rps6ka1-201
(1)
|
Ensembl | 3,402 nt | ||
| mRNA |
rps6ka1-202
(1)
|
Ensembl | 5,367 nt | ||
| mRNA |
rps6ka1-203
(1)
|
Ensembl | 560 nt | ||
| mRNA |
rps6ka1-204
(1)
|
Ensembl | 486 nt | ||
| mRNA |
rps6ka1-205
(1)
|
Ensembl | 6,251 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-160F23 | ZFIN Curated Data | |
| Contained in | BAC | CH211-195M7 | ||
| Contained in | BAC | CH211-280H1 | ZFIN Curated Data | |
| Encodes | EST | fc56h07 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:152654 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191438 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001077775 (1) | 4992 nt | ||
| Genomic | GenBank:AL805945 | 212604 nt | ||
| Polypeptide | UniProtKB:A0AB32TB58 (1) | 763 aa |
- Kahsay, A., Rodriguez-Marquez, E., López-Pérez, A., Hörnblad, A., von Hofsten, J. (2022) Pax3 loss of function delays tumour progression in kRAS-induced zebrafish rhabdomyosarcoma models. Scientific Reports. 12:17149
- Boswell, M., Boswell, W., Lu, Y., Savage, M., Walter, R.B. (2020) Deconvoluting Wavelengths Leading to Fluorescent Light Induced Inflammation and Cellular Stress in Zebrafish (Danio rerio). Scientific Reports. 10:3321
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Frank, D.F., Miller, G.W., Connon, R.E., Geist, J., Lein, P.J. (2017) Transcriptomic profiling of mTOR and ryanodine receptor signaling molecules in developing zebrafish in the absence and presence of PCB 95. PeerJ. 5:e4106
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hu, S.N., Yu, H., Zhang, Y.B., Wu, Z.L., Yan, Y.C., Li, Y.X., Li, Y.Y., and Li, Y.P. (2012) Splice blocking of zygotic sox31 leads to developmental arrest shortly after Mid-Blastula Transition and induces apoptosis in zebrafish. FEBS letters. 586(3):222-228
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
- Asakawa, K., Suster, M.L., Mizusawa, K., Nagayoshi, S., Kotani, T., Urasaki, A., Kishimoto, Y., Hibi, M., and Kawakami, K. (2008) Genetic dissection of neural circuits by Tol2 transposon-mediated Gal4 gene and enhancer trapping in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 105(4):1255-1260
- Lemeer, S., Pinkse, M.W., Mohammed, S., van Breukelen, B., den Hertog, J., Slijper, M., and Heck, A.J. (2008) Online Automated in Vivo Zebrafish Phosphoproteomics: From Large-Scale Analysis Down to a Single Embryo. Journal of Proteome Research. 7(4):1555-1564
- Kohn, M., Hogel, J., Vogel, W., Minich, P., Kehrer-Sawatzki, H., Graves, J.A., and Hameister, H. (2006) Reconstruction of a 450-My-old ancestral vertebrate protokaryotype. Trends in genetics : TIG. 22(4):203-210
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