Gene
acaca
- ID
- ZDB-GENE-060526-74
- Name
- acetyl-CoA carboxylase alpha
- Symbol
- acaca Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable acetyl-CoA carboxylase activity. Acts upstream of or within response to (R)-carnitine. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in female organism; liver; male organism; subcutaneous fat; and visceral fat. Orthologous to human ACACA (acetyl-CoA carboxylase alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 36 figures from 31 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb617 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| ihb621 | Allele with one delins | Unknown | Unknown | CRISPR | |
| sa2214 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20542 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa26588 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33724 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40568 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-acaca | Zebrafish Nomenclature Committee |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Acetyl-CoA carboxylase deficiency | 613933 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR001882 | Biotin-binding site |
| Domain | IPR000089 | Biotin/lipoyl attachment |
| Domain | IPR005479 | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain |
| Domain | IPR005481 | Biotin carboxylase-like, N-terminal domain |
| Domain | IPR005482 | Biotin carboxylase, C-terminal |
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Domain Details Per Protein
| Protein | Length | Acetyl-CoA carboxylase | Acetyl-CoA carboxylase, BT domain | Acetyl-CoA carboxylase, central domain | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta | Acetyl-coenzyme A carboxyltransferase, C-terminal | Acetyl-coenzyme A carboxyltransferase, N-terminal | ATP-grasp fold | ATP-grasp fold, subdomain 1 | Biotin-binding site | Biotin carboxylase, C-terminal | Biotin carboxylase-like, N-terminal domain | Biotin carboxylation domain | Biotin/lipoyl attachment | Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain | ClpP/crotonase-like domain superfamily | Pre-ATP-grasp domain superfamily | Rudiment single hybrid motif | Single hybrid motif |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6YZ52
|
2349 | ||||||||||||||||||
|
UniProtKB:A0A8M9PK80
|
2425 | ||||||||||||||||||
|
UniProtKB:A0A8M9QE20
|
2326 | ||||||||||||||||||
|
UniProtKB:A0A2R8QJA0
|
2375 | ||||||||||||||||||
|
UniProtKB:A0A8M9Q3F9
|
2348 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-199D18 | ZFIN Curated Data | |
| Contained in | BAC | CH211-250O16 | ZFIN Curated Data | |
| Encodes | EST | fj43d01 | ||
| Encodes | EST | IMAGE:7138837 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001271308 (1) | 8344 nt | ||
| Genomic | GenBank:AL935115 (1) | 187326 nt | ||
| Polypeptide | UniProtKB:A0A8M9PK80 (1) | 2425 aa |
- Gao, P., Chang, C., Liang, J., Du, F., Zhang, R. (2024) Embryonic Amoxicillin Exposure Has Limited Impact on Liver Development but Increases Susceptibility to NAFLD in Zebrafish Larvae. International Journal of Molecular Sciences. 25(5):
- Jia, J.Y., Chen, G.H., Shu, T.T., Lou, Q.Y., Jin, X., He, J.Y., Xiao, W.H., Zhai, G., Yin, Z. (2024) Androgen signaling inhibits de novo lipogenesis to alleviate lipid deposition in zebrafish. Zoological research. 45:355366355-366
- Li, X., Liu, C., Zhang, R., Li, Y., Ye, D., Wang, H., He, M., Sun, Y. (2024) Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. The Journal of biological chemistry. 300(7):107405
- Wang, J.X., Zhang, Y.Y., Qian, Y.C., Qian, Y.F., Jin, A.H., Wang, M., Luo, Y., Qiao, F., Zhang, M.L., Chen, L.Q., Du, Z.Y. (2024) Inhibition of mitochondrial citrate shuttle alleviates metabolic syndromes induced by high-fat diet. American journal of physiology. Cell physiology. 327(3):C737-C749
- Wang, X., Li, X., Wang, Y., Ren, Z., Du, X., Gao, J., Ji, G., Liu, Z. (2024) Nkx1.2 deletion decreases fat production in zebrafish. Obesity (Silver Spring, Md.). 32(7):1315-1328
- Yang, Y., Zhang, X., Zhao, Q., Zhang, J., Lou, X. (2024) Compromised COPII vesicle trafficking leads to glycogenic hepatopathy in zebrafish. Disease models & mechanisms. 17(9):
- Grepper, D., Tabasso, C., Aguettaz, A., Martinotti, A., Ebrahimi, A., Lagarrigue, S., Amati, F. (2023) Methodological advancements in organ-specific ectopic lipid quantitative characterization: Effects of high fat diet on muscle and liver intracellular lipids. Molecular metabolism. 68:101669
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Liu, R., Lu, Y., Peng, X., Jia, J., Ruan, Y., Shi, S., Shu, T., Li, T., Jin, X., Zhai, G., He, J., Lou, Q., Yin, Z. (2023) Enhanced insulin activity achieved in VDRa/b ablation zebrafish. Frontiers in endocrinology. 14:10546651054665
- Park, K.H., Makki, H.M.M., Kim, S.H., Chung, H.J., Jung, J. (2023) Narirutin ameliorates alcohol-induced liver injury by targeting MAPK14 in zebrafish larvae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 166:115350115350
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