Gene
fgf16
- ID
- ZDB-GENE-060427-3
- Name
- fibroblast growth factor 16
- Symbol
- fgf16 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Acts upstream of or within nervous system development and pectoral fin morphogenesis. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including forebrain; otic vesicle; pectoral fin bud; tail bud; and ventral fin fold. Human ortholog(s) of this gene implicated in syndactyly type 8. Orthologous to human FGF16 (fibroblast growth factor 16).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-fgf16 | N/A | (2) |
| MO2-fgf16 | N/A | (2) |
| MO3-fgf16 | N/A | Laurell et al., 2014 |
| MO4-fgf16 | N/A | Laurell et al., 2014 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| syndactyly type 8 | Alliance | Metacarpal 4-5 fusion | 309630 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytokine IL1/FGF | Fibroblast growth factor family |
|---|---|---|---|
|
UniProtKB:Q2HXK8
|
203 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-65A17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194912 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:194923 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001040407 (1) | 612 nt | ||
| Genomic | GenBank:CR855117 (2) | 171108 nt | ||
| Polypeptide | UniProtKB:Q2HXK8 (1) | 203 aa |
- Cudak, N., López-Delgado, A.C., Keil, S., Knopf, F. (2023) Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene expression patterns : GEP. 48:119307
- Gallegos, T.F., Kamei, C.N., Rohly, M., Drummond, I.A. (2019) Fibroblast growth factor signaling mediates progenitor cell aggregation and nephron regeneration in the adult zebrafish kidney. Developmental Biology. 454(1):44-51
- Sugimoto, K., Hui, S.P., Sheng, D.Z., Kikuchi, K. (2017) Dissection of zebrafish shha function using site-specific targeting with a Cre-dependent genetic switch.. eLIFE. 6
- Shibata, E., Yokota, Y., Horita, N., Kudo, A., Abe, G., Kawakami, K., Kawakami, A. (2016) Fgf signalling controls diverse aspects of fin regeneration. Development (Cambridge, England). 143:2920-9
- Laurell, T., Nilsson, D., Hofmeister, W., Lindstrand, A., Ahituv, N., Vandermeer, J., Amilon, A., Annerén, G., Arner, M., Pettersson, M., Jäntti, N., Rosberg, H.E., Cattini, P.A., Nordenskjöld, A., Mäkitie, O., Grigelioniene, G., Nordgren, A. (2014) Identification of three novel FGF16 mutations in X-linked recessive fusion of the fourth and fifth metacarpals and possible correlation with heart disease. Molecular genetics & genomic medicine. 2:402-11
- Miyake, A., Chitose, T., Kamei, E., Murakami, A., Nakayama, Y., Konishi, M., Itoh, N. (2014) Fgf16 Is Required for Specification of GABAergic Neurons and Oligodendrocytes in the Zebrafish Forebrain. PLoS One. 9:e110836
- Muto, A., Ikeda, S., Lopez-Burks, M.E., Kikuchi, Y., Calof, A.L., Lander, A.D., Schilling, T.F. (2014) Nipbl and Mediator Cooperatively Regulate Gene Expression to Control Limb Development. PLoS Genetics. 10:e1004671
- Jackman, W.R., Davies, S.H., Lyons, D.B., Stauder, C.K., Denton-Schneider, B.R., Jowdry, A., Aigler, S.R., Vogel, S.A., Stock, D.W. (2013) Manipulation of Fgf and Bmp signaling in teleost fishes suggests potential pathways for the evolutionary origin of multicuspid teeth. Evolution & development. 15:107-18
- Rissone, A., Sangiorgio, L., Monopoli, M., Beltrame, M., Zucchi, I., Bussolino, F., Arese, M., and Cotelli, F. (2010) Characterization of the neuroligin gene family expression and evolution in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(2):688-702
- Ota, S., Tonou-Fujimori, N., and Yamasu, K. (2009) The roles of the FGF signal in zebrafish embryos analyzed using constitutive activation and dominant-negative suppression of different FGF receptors. Mechanisms of Development. 126(1-2):1-17
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