Gene
plin2
- ID
- ZDB-GENE-050913-12
- Name
- perilipin 2
- Symbol
- plin2 Nomenclature History
- Previous Names
-
- adfp
- zgc:110411 (1)
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to be involved in lipid storage and positive regulation of triglyceride storage. Located in lipid droplet. Is expressed in digestive system and liver. Orthologous to human PLIN2 (perilipin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:110411 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR004279 | Perilipin |
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Domain Details Per Protein
| Protein | Length | Perilipin |
|---|---|---|
|
UniProtKB:F1QWT0
|
444 | |
|
UniProtKB:A0A8M9P703
|
324 | |
|
UniProtKB:Q4V9M9
|
428 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(-3.5ubb:plin2-tdTomato) |
|
| 1 | (2) | |
| Tg(fabp2:EGFP-plin2) |
|
| 1 | Wilson et al., 2021 | |
| Tg(fabp10a:EGFP-plin2) |
|
| 1 | Wilson et al., 2021 | |
| Tg(hsp70l:EGFP-plin2) |
|
| 1 | Wilson et al., 2021 | |
| Tg(plin2:Tomato) |
|
| 1 | Zhang et al., 2018 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-24O10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-264N17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:110411 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191699 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001030262 (1) | 1410 nt | ||
| Genomic | GenBank:BX572630 (2) | 174316 nt | ||
| Polypeptide | UniProtKB:F1QWT0 (1) | 444 aa |
- Jin, Y., Kozan, D., Young, E.D., Hensley, M., Shen, M.C., Wen, J., Moll, T., Anderson, J.L., Kozan, H., Rawls, J.F., Farber, S.A. (2024) A high-cholesterol zebrafish diet promotes hypercholesterolemia and fasting-associated liver steatosis. Journal of Lipid Research. 65(10):100637
- Zhao, C., Li, J., Hu, Y., Li, L., Yu, M., Huang, Y., Zhang, T., Shang, H., Zou, Z. (2024) (+)/(-)-Gerbeloid A, a pair of unprecedented coumarin-based polycyclic meroterpenoid enantiomers from Gerbera piloselloides: Structural elucidation, semi-synthesis, and lipid-lowering activity. Acta pharmaceutica Sinica. B. 14:265726682657-2668
- Gora, A.H., Rehman, S., Dias, J., Fernandes, J.M.O., Olsvik, P.A., Sørensen, M., Kiron, V. (2023) Protective mechanisms of a microbial oil against hypercholesterolemia: evidence from a zebrafish model. Frontiers in nutrition. 10:11611191161119
- Grepper, D., Tabasso, C., Aguettaz, A., Martinotti, A., Ebrahimi, A., Lagarrigue, S., Amati, F. (2023) Methodological advancements in organ-specific ectopic lipid quantitative characterization: Effects of high fat diet on muscle and liver intracellular lipids. Molecular metabolism. 68:101669
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Sun, Y., Heng, J., Liu, F., Zhang, S., Liu, P. (2023) Isolation and proteomic study of fish liver lipid droplets. Biophysics reports. 9:120133120-133
- Montal, E., Lumaquin, D., Ma, Y., Suresh, S., White, R.M. (2022) Modeling the effects of genetic and diet induced obesity on melanoma progression in zebrafish. Disease models & mechanisms. 16(1):
- Mu, X., Qi, S., Wang, H., Yuan, L., Wang, C., Li, Y., Qiu, J. (2022) Bisphenol analogues induced metabolic effects through eliciting intestinal cell heterogeneous response. Environment International. 165:107287
- Han, S.L., Qian, Y.C., Limbu, S.M., Wang, J., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2021) Lipolysis and lipophagy play individual and interactive roles in regulating triacylglycerol and cholesterol homeostasis and mitochondrial form in zebrafish. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1866(9):158988
- Lumaquin, D., Johns, E., Montal, E., Weiss, J.M., Ola, D., Abuhashem, A., White, R.M. (2021) An in vivo reporter for tracking lipid droplet dynamics in transparent zebrafish. eLIFE. 10:
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