Gene
acsl3a
- ID
- ZDB-GENE-050420-181
- Name
- acyl-CoA synthetase long chain family member 3a
- Symbol
- acsl3a Nomenclature History
- Previous Names
-
- si:dkeyp-109h9.2
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA metabolic process; and neuron differentiation. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum; lipid droplet; and plasma membrane. Is expressed in several structures, including digestive system; eye; gill; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in asthma; breast cancer; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Lopes-Marques et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la010316Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019418Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la019419Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa8864 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16715 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32062 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa35990 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39067 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42620 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | AMP-binding, conserved site | AMP-binding enzyme, C-terminal domain superfamily | AMP-dependent synthetase/ligase domain | ANL, N-terminal domain |
|---|---|---|---|---|---|
|
UniProtKB:Q1LVA8
|
713 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
acsl3a-201
(1)
|
Ensembl | 2,244 nt | ||
| mRNA |
acsl3a-202
(1)
|
Ensembl | 2,734 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(fabp2:EGFP-acsl3a) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-109H9 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001045128 (1) | 2142 nt | ||
| Genomic | GenBank:BX890602 (1) | 191296 nt | ||
| Polypeptide | UniProtKB:Q1LVA8 (1) | 713 aa |
- Grepper, D., Tabasso, C., Aguettaz, A., Martinotti, A., Ebrahimi, A., Lagarrigue, S., Amati, F. (2023) Methodological advancements in organ-specific ectopic lipid quantitative characterization: Effects of high fat diet on muscle and liver intracellular lipids. Molecular metabolism. 68:101669
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Gu, Q., Ali, S.F., Kanungo, J. (2020) Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Journal of applied toxicology : JAT. 41(2):256-264
- Quinlivan, V.H., Farber, S.A. (2017) Lipid Uptake, Metabolism, and Transport in the Larval Zebrafish. Frontiers in endocrinology. 8:319
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Cruz-Garcia, L., Schlegel, A. (2014) Lxr-driven enterocyte lipid droplet formation delays transport of ingested lipids. Journal of Lipid Research. 55(9):1944-58
- Lopes-Marques, M., Cunha, I., Reis-Henriques, M.A., Santos, M.M., and Castro, L.F. (2013) Diversity and history of the long-chain acyl-CoA synthetase (Acsl) gene family in vertebrates. BMC Developmental Biology. 13:271
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
- Watkins, P.A., Maiguel, D., Jia, Z., and Pevsner, J. (2007) Evidence for 26 distinct acyl-coenzyme A synthetase genes in the human genome. Journal of Lipid Research. 48(12):2736-2750
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