Gene
slc27a4
- ID
- ZDB-GENE-050417-248
- Name
- solute carrier family 27 member 4
- Symbol
- slc27a4 Nomenclature History
- Previous Names
-
- fatp4 (1)
- sb:eu977
- zgc:112138
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable long-chain fatty acid transmembrane transporter activity and oleoyl-CoA ligase activity. Predicted to be involved in long-chain fatty acid import into cell; long-chain fatty acid metabolic process; and medium-chain fatty acid transport. Predicted to act upstream of or within lipid metabolic process. Predicted to be active in endoplasmic reticulum membrane and plasma membrane. Is expressed in intestinal bulb and intestine. Orthologous to human SLC27A4 (solute carrier family 27 member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 12 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu977 (3 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-slc27a4 | (2) | |
| MO1-slc27a4 | N/A | Tilghman et al., 2019 |
1 - 2 of 2
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Ichthyosis prematurity syndrome | 608649 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020845 | AMP-binding, conserved site |
| Conserved_site | IPR022272 | Lipocalin family conserved site |
| Domain | IPR000873 | AMP-dependent synthetase/ligase domain |
| Domain | IPR025110 | AMP-binding enzyme, C-terminal domain |
| Homologous_superfamily | IPR042099 | ANL, N-terminal domain |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Additional Resources | Length | AMP-binding, conserved site | AMP-binding enzyme, C-terminal domain | AMP-binding enzyme, C-terminal domain superfamily | AMP-dependent synthetase/ligase domain | ANL, N-terminal domain | Lipocalin family conserved site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q567D7 | InterPro | 643 |
1 - 1 of 1
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
slc27a4-201
(1)
|
Ensembl | 2,460 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-264F7 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-21P9 | ZFIN Curated Data | |
| Encodes | EST | eu977 | Thisse et al., 2005 | |
| Encodes | cDNA | MGC:112138 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017737 (1) | 2460 nt | ||
| Genomic | GenBank:BX005370 (2) | 208765 nt | ||
| Polypeptide | UniProtKB:Q567D7 (1) | 643 aa |
- Wei, X., Tan, X., Chen, Q., Jiang, Y., Wu, G., Ma, X., Fu, J., Li, Y., Gang, K., Yang, Q., Ni, R., He, J., Luo, L. (2023) Extensive jejunal injury is repaired by migration and transdifferentiation of ileal enterocytes in zebrafish. Cell Reports. 42:112660112660
- Kamoshita, M., Kumar, R., Anteghini, M., Kunze, M., Islinger, M., Martins Dos Santos, V., Schrader, M. (2022) Insights Into the Peroxisomal Protein Inventory of Zebrafish. Frontiers in Physiology. 13:822509
- Zhao, G., Hu, J., Gao, M., Zhu, Y., Hong, Y. (2022) Excessive selenium affects neural development and locomotor behavior of zebrafish embryos. Ecotoxicology and environmental safety. 238:113611
- Gu, Q., Ali, S.F., Kanungo, J. (2020) Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Journal of applied toxicology : JAT. 41(2):256-264
- Zhao, Y., Cao, X., Fu, L., Gao, J. (2020) n-3 PUFA reduction caused by fabp2 deletion interferes with triacylglycerol metabolism and cholesterol homeostasis in fish. Applied Microbiology and Biotechnology. 104(5):2149-2161
- Dooley, C.M., Wali, N., Sealy, I.M., White, R.J., Stemple, D.L., Collins, J.E., Busch-Nentwich, E.M. (2019) The gene regulatory basis of genetic compensation during neural crest induction. PLoS Genetics. 15:e1008213
- Shi, G., Cui, Q., Wang, J., Guo, H., Pan, Y., Sheng, N., Guo, Y., Dai, J. (2019) Chronic exposure to 6:2 chlorinated polyfluorinated ether sulfonate acid (F-53B) induced hepatotoxic effects in adult zebrafish and disrupted the PPAR signaling pathway in their offspring. Environmental pollution (Barking, Essex : 1987). 249:550-559
- Tilghman, J.M., Ling, A.Y., Turner, T.N., Sosa, M.X., Krumm, N., Chatterjee, S., Kapoor, A., Coe, B.P., Nguyen, K.H., Gupta, N., Gabriel, S., Eichler, E.E., Berrios, C., Chakravarti, A. (2019) Molecular Genetic Anatomy and Risk Profile of Hirschsprung's Disease. The New England Journal of Medicine. 380:1421-1432
- Tuttle, M., Dalman, M.R., Liu, Q., Londraville, R.L. (2019) Leptin-a mediates transcription of genes that participate in central endocrine and phosphatidylinositol signaling pathways in 72-hour embryonic zebrafish (Danio rerio). PeerJ. 7:e6848
- Zhu, Y., Tan, Q., Zhang, L., Yao, J., Zhou, H., Hu, P., Liang, X., Liu, H. (2019) The migration of docosahexenoic acid (DHA) to the developing ovary of female zebrafish (Danio rerio). Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. 233:97-105
1 - 10 of 16
Show