Gene
nr1h3
- ID
- ZDB-GENE-050410-7
- Name
- nuclear receptor subfamily 1, group H, member 3
- Symbol
- nr1h3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Enables nuclear receptor activity. Acts upstream of or within several processes, including embryonic viscerocranium morphogenesis; regulation of intestinal lipid absorption; and regulation of transcription by RNA polymerase II. Predicted to be part of RNA polymerase II transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including brain; digestive system; eye; heart; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in cerebral infarction; cerebrovascular disease; myocardial infarction; and obesity. Orthologous to human NR1H3 (nuclear receptor subfamily 1 group H member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 17 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:113339 (7 images)
- IMAGE:7141239 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nr1h3 | (2) | |
| MO1-nr1h3 | N/A | (3) |
| MO2-nr1h3 | N/A | Pinto et al., 2016 |
| TALEN1-nr1h3 | (3) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000536 | Nuclear hormone receptor, ligand-binding domain |
| Domain | IPR001628 | Zinc finger, nuclear hormone receptor-type |
| Family | IPR001723 | Nuclear hormone receptor |
| Family | IPR023257 | Liver X receptor |
| Family | IPR050234 | Nuclear hormone receptor family NR1 subfamily |
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Domain Details Per Protein
| Protein | Length | Liver X receptor | Nuclear hormone receptor | Nuclear hormone receptor family NR1 subfamily | Nuclear hormone receptor, ligand-binding domain | Nuclear hormone receptor-like domain superfamily | Zinc finger, NHR/GATA-type | Zinc finger, nuclear hormone receptor-type |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IVP0
|
441 |
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Interactions and Pathways
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(actb2:EGFP-nr1h3) |
|
| 1 | (3) | |
| Tg(fabp2:EGFP-nr1h3) |
|
| 1 | (4) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-223J12 | ZFIN Curated Data | |
| Encodes | EST | fd59b01 | ||
| Encodes | EST | IMAGE:7141239 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:113339 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158542 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191690 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001017545 (1) | 4972 nt | ||
| Genomic | GenBank:FO704901 (1) | 38936 nt | ||
| Polypeptide | UniProtKB:A0A0R4IVP0 (1) | 441 aa |
- Xu, Y., Guo, R., Huang, T., Guo, C. (2024) miRNA-7145-cuedc2 axis controls hematopoiesis through JAK1/STAT3 signaling pathway. Cell death discovery. 10:209209
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Ahi, E.P., Tsakoumis, E., Brunel, M., Schmitz, M. (2021) Transcriptional study reveals a potential leptin-dependent gene regulatory network in zebrafish brain. Fish physiology and biochemistry. 47(4):1283-1298
- Marqueño, A., Flores, C., Casado, M., Porte, C. (2021) Dysregulation of lipid metabolism in PLHC-1 and ZFL cells exposed to tributyltin an all-trans retinoic acid. Aquatic toxicology (Amsterdam, Netherlands). 231:105733
- Marqueño, A., Pérez-Albaladejo, E., Denslow, N.D., Bowden, J.A., Porte, C. (2021) Untargeted lipidomics reveals the toxicity of bisphenol A bis(3-chloro-2- hydroxypropyl) ether and bisphenols A and F in zebrafish liver cells. Ecotoxicology and environmental safety. 219:112311
- Raby, L., Völkel, P., Hasanpour, S., Cicero, J., Toillon, R.A., Adriaenssens, E., Van Seuningen, I., Le Bourhis, X., Angrand, P.O. (2021) Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish. Cells. 10(11):
- Thiel, W., Esposito, E.J., Findley, A.P., Blume, Z.I., Mitchell, D.M. (2021) Modulation of retinoid-X-receptors differentially regulates expression of apolipoprotein genes apoc1 and apoeb by zebrafish microglia. Biology Open. 11(1):
- Wang, W., Zhang, J., Li, Z., Gu, J., Qin, J., Li, J., Zhang, X., Ru, S. (2021) Bisphenol S exposure accelerates the progression of atherosclerosis in zebrafish embryo-larvae. Journal of hazardous materials. 426:128042
- Wen, J., Mercado, G.P., Volland, A., Doden, H.L., Lickwar, C.R., Crooks, T., Kakiyama, G., Kelly, C., Cocchiaro, J.L., Ridlon, J.M., Rawls, J.F. (2021) Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine. Science advances. 7(30)
- Zhu, Y., Yang, D., Duan, X., Zhang, Y., Chen, D., Gong, Z., Liu, C. (2021) Perfluorooctane Sulfonate Promotes Doxycycline-induced Liver Tumor Progression in Male Krasv12 Transgenic Zebrafish. Environmental research. 196:110962
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