Gene
angptl4
- ID
- ZDB-GENE-041111-222
- Name
- angiopoietin-like 4
- Symbol
- angptl4 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable enzyme inhibitor activity. Acts upstream of or within apoptotic process involved in blood vessel morphogenesis and response to bacterium. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in endocrine pancreas; intestinal epithelium; intestine; and liver. Orthologous to human ANGPTL4 (angiopoietin like 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7144703 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Serbanovic-Canic et al., 2017
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb725 | Allele with one deletion | Exon 3 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-angptl4 | Zebrafish Nomenclature Committee | |
| MO1-angptl4 | N/A | Serbanovic-Canic et al., 2017 |
| MO2-angptl4 | N/A | (2) |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Plasma triglyceride level QTL, low | 615881 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020837 | Fibrinogen, conserved site |
| Domain | IPR002181 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain |
| Family | IPR037579 | Fibrinogen/angiopoietin-like |
| Homologous_superfamily | IPR014716 | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 |
| Homologous_superfamily | IPR036056 | Fibrinogen-like, C-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen/angiopoietin-like | Fibrinogen, conserved site | Fibrinogen-like, C-terminal |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1NYZ0 | InterPro | 460 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
angptl4-202
(1)
|
Ensembl | 2,397 nt | ||
| ncRNA |
angptl4-002
(1)
|
Ensembl | 224 nt | ||
| ncRNA |
angptl4-003
(1)
|
Ensembl | 492 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg1(-1angptl4:GFP) |
|
| 1 | (2) | |
| Tg1(-3.5angptl4:GFP) |
|
| 1 | (2) | |
| Tg1(-5.2angptl4:GFP) |
|
| 1 | (2) | |
| Tg(-1angptl4:GFP) |
|
| 1 | (2) | |
| Tg1(angptl4-Mmu.Fos:GFP) |
|
| 1 | (2) | |
| Tg1(angptl4-Mmu.Fos:TdTomato) |
|
| 1 | (2) | |
| Tg(-3.5angptl4:GFP) |
|
| 1 | (2) | |
| Tg3(angptl4-Mmu.Fos:GFP) |
|
| 1 | (3) | |
| Tg4(angptl4-Mmu.Fos:GFP) |
|
| 1 | (2) | |
| Tg(-5.2angptl4:GFP) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | RP71-39B20 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7144703 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001256203 (1) | 2402 nt | ||
| Genomic | GenBank:BX530024 (1) | 146464 nt | ||
| Polypeptide | UniProtKB:A0A8M1NYZ0 (1) | 460 aa |
- Bowley, G., Irving, S., Hoefer, I., Wilkinson, R., Pasterkamp, G., Darwish, H.M.S., White, S., Francis, S.E., Chico, T., Noel, E., Serbanovic-Canic, J., Evans, P.C. (2024) Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation. Scientific Reports. 14:3013030130
- Alnassar, N., Hillman, C., Fontana, B.D., Robson, S.C., Norton, W.H.J., Parker, M.O. (2023) angptl4 gene expression as a marker of adaptive homeostatic response to social isolation across the lifespan in zebrafish. Neurobiology of aging. 131:209221209-221
- Guirgis, F.W., Jacob, V., Wu, D., Henson, M., Daly-Crews, K., Hopson, C., Black, L.P., DeVos, E.L., Sulaiman, D., Labilloy, G., Brusko, T.M., Shavit, J.A., Bertrand, A., Feldhammer, M., Baskovich, B., Graim, K., Datta, S., Reddy, S.T. (2023) DHCR7 Expression Predicts Porsusor Outcomes and Mortality From Sepsis. Critical care explorations. 5:e0929e0929
- Sun, W., Zhang, X., Qiao, Y., Griffin, N., Zhang, H., Wang, L., Liu, H. (2023) Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish. Ecotoxicology and environmental safety. 259:115020115020
- Wang, A., Wan, X., Zhuang, P., Jia, W., Ao, Y., Liu, X., Tian, Y., Zhu, L., Huang, Y., Yao, J., Wang, B., Wu, Y., Xu, Z., Wang, J., Yao, W., Jiao, J., Zhang, Y. (2023) High fried food consumption impacts anxiety and depression due to lipid metabolism disturbance and neuroinflammation. Proceedings of the National Academy of Sciences of the United States of America. 120:e2221097120e2221097120
- Chen, S., Ye, W., Clements, K.D., Zan, Z., Zhao, W., Zou, H., Wang, G., Wu, S. (2022) Bacillus licheniformis FA6 Affects Zebrafish Lipid Metabolism through Promoting Acetyl-CoA Synthesis and Inhibiting β-Oxidation. International Journal of Molecular Sciences. 24(1):
- Ogawa, Y., Corbo, J.C. (2021) Partitioning of gene expression among zebrafish photoreceptor subtypes. Scientific Reports. 11:17340
- Pottie, L., Van Gool, W., Vanhooydonck, M., Hanisch, F.G., Goeminne, G., Rajkovic, A., Coucke, P., Sips, P., Callewaert, B. (2021) Loss of zebrafish atp6v1e1b, encoding a subunit of vacuolar ATPase, recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures. PLoS Genetics. 17:e1009603
- Pereiro, P., Librán-Pérez, M., Figueras, A., Novoa, B. (2020) Conserved function of zebrafish (Danio rerio) Gdf15 as a sepsis tolerance mediator. Developmental and comparative immunology. 109:103698
- Viana, J., Wildman, N., Hannon, E., Farbos, A., Neill, P.O., Moore, K., van Aerle, R., Paull, G., Santos, E., Mill, J. (2020) Clozapine-induced transcriptional changes in the zebrafish brain. NPJ schizophrenia. 6:3
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