Gene
cpt1b
- ID
- ZDB-GENE-041010-9
- Name
- carnitine palmitoyltransferase 1B (muscle)
- Symbol
- cpt1b Nomenclature History
- Previous Names
-
- cpt1al (1)
- zgc:103709
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to enable carnitine O-palmitoyltransferase activity. Acts upstream of or within energy homeostasis; response to (R)-carnitine; and response to bacterium. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adipose tissue; digestive system; eye; female organism; and integument. Orthologous to human CPT1B (carnitine palmitoyltransferase 1B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103709 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR032476 | Carnitine O-palmitoyltransferase, N-terminal |
| Domain | IPR039551 | Choline/carnitine acyltransferase domain |
| Family | IPR000542 | Acyltransferase ChoActase/COT/CPT |
| Homologous_superfamily | IPR023213 | Chloramphenicol acetyltransferase-like domain superfamily |
| Homologous_superfamily | IPR042231 | Choline/Carnitine o-acyltransferase, domain 2 |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Acyltransferase ChoActase/COT/CPT | Carnitine O-palmitoyltransferase, N-terminal | Chloramphenicol acetyltransferase-like domain superfamily | Choline/carnitine acyltransferase domain | Choline/Carnitine o-acyltransferase, domain 2 |
|---|---|---|---|---|---|---|---|
| UniProtKB:F6P7Z9 | InterPro | 770 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-218C17 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103709 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001328192 (1) | 2968 nt | ||
| Genomic | GenBank:BX276107 (1) | 46296 nt | ||
| Polypeptide | UniProtKB:F6P7Z9 (1) | 770 aa |
- Freeburg, S.H., Shwartz, A., Kemény, L.V., Smith, C.J., Weeks, O., Miller, B.M., PenkoffLidbeck, N., Fisher, D.E., Evason, K.J., Goessling, W. (2024) Hepatocyte vitamin D receptor functions as a nutrient sensor that regulates energy storage and tissue growth in zebrafish. Cell Reports. 43:114393114393
- Li, X., Liu, C., Zhang, R., Li, Y., Ye, D., Wang, H., He, M., Sun, Y. (2024) Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. The Journal of biological chemistry. 300(7):107405
- Zhao, Y., Lv, H., Yu, C., Liang, J., Yu, H., Du, Z., Zhang, R. (2024) Systemic inhibition of mitochondrial fatty acid β-oxidation impedes zebrafish ventricle regeneration. Biochimica et biophysica acta. Molecular basis of disease. 1870(7):167442
- Grepper, D., Tabasso, C., Aguettaz, A., Martinotti, A., Ebrahimi, A., Lagarrigue, S., Amati, F. (2023) Methodological advancements in organ-specific ectopic lipid quantitative characterization: Effects of high fat diet on muscle and liver intracellular lipids. Molecular metabolism. 68:101669
- Liu, R., Lu, Y., Peng, X., Jia, J., Ruan, Y., Shi, S., Shu, T., Li, T., Jin, X., Zhai, G., He, J., Lou, Q., Yin, Z. (2023) Enhanced insulin activity achieved in VDRa/b ablation zebrafish. Frontiers in endocrinology. 14:10546651054665
- Xu, S.S., Li, Y., Wang, H.P., Chen, W.B., Wang, Y.Q., Song, Z.W., Liu, H., Zhong, S., Sun, Y.H. (2023) Depletion of stearoyl-CoA desaturase (scd) leads to fatty liver disease and defective mating behavior in zebrafish. Zoological research. 44:63-77
- Zhou, W.H., Luo, Y., Li, R.X., Degrace, P., Jourdan, T., Qiao, F., Chen, L.Q., Zhang, M.L., Du, Z.Y. (2023) Inhibition of mitochondrial fatty acid β-oxidation activates mTORC1 pathway and protein synthesis via Gcn5-dependent acetylation of raptor in zebrafish. The Journal of biological chemistry. 299(10):105220
- Kurchaba, N., Charette, J.M., LeMoine, C.M.R. (2022) Metabolic consequences of PGC-1α dysregulation in adult zebrafish muscle. American journal of physiology. Regulatory, integrative and comparative physiology. 323(3):R319-R330
- Lai, C.Y., Yeh, K.Y., Lin, C.Y., Hsieh, Y.W., Lai, H.H., Chen, J.R., Hsu, C.C., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF-β, and STAT3 Signaling. Cancers. 13(5):
- Lee, H., Gao, Y., Ko, E., Lee, J., Lee, H.K., Lee, S., Choi, M., Shin, S., Park, Y.H., Moon, H.B., Uppal, K., Kim, K.T. (2021) Nonmonotonic response of type 2 diabetes by low concentration organochlorine pesticide mixture: Findings from multi-omics in zebrafish. Journal of hazardous materials. 416:125956
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