Gene
acox1
- ID
- ZDB-GENE-041010-219
- Name
- acyl-CoA oxidase 1, palmitoyl
- Symbol
- acox1 Nomenclature History
- Previous Names
-
- wu:fb59h12
- zgc:114033
- zgc:92584
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable fatty acid binding activity; flavin adenine dinucleotide binding activity; and palmitoyl-CoA oxidase activity. Predicted to be involved in fatty acid beta-oxidation using acyl-CoA oxidase and very long-chain fatty acid metabolic process. Predicted to act upstream of or within fatty acid beta-oxidation. Predicted to be active in peroxisome. Is expressed in several structures, including female organism; immature eye; liver; pleuroperitoneal region; and subcutaneous fat. Human ortholog(s) of this gene implicated in Mitchell syndrome and peroxisomal acyl-CoA oxidase deficiency. Orthologous to human ACOX1 (acyl-CoA oxidase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 19 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92584 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-acox1 | Zebrafish Nomenclature Committee |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Mitchell syndrome | Alliance | Mitchell syndrome | 618960 |
| peroxisomal acyl-CoA oxidase deficiency | Alliance | Peroxisomal acyl-CoA oxidase deficiency | 264470 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Acyl-CoA dehydrogenase-like, C-terminal | Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain superfamily | Acyl-CoA dehydrogenase/oxidase, N-terminal domain superfamily | Acyl-CoA oxidase | Acyl-CoA oxidase, C-alpha1 domain | Acyl-CoA oxidase, C-terminal | Acyl-CoA oxidase/dehydrogenase, middle domain superfamily | Acyl-coenzyme A oxidase, N-terminal | Peroxisomal acyl-coenzyme A oxidase |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1R071 | InterPro | 660 | |||||||||
| UniProtKB:Q5XIZ4 | InterPro | 660 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-89I1 | ZFIN Curated Data | |
| Encodes | EST | fb59h12 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92584 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:114033 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001005933 (1) | 2613 nt | ||
| Genomic | GenBank:CR391945 (1) | 103052 nt | ||
| Polypeptide | UniProtKB:F1R071 (1) | 660 aa |
- Li, Q., Wu, L., Wang, G., Zheng, F., Sun, J., Zhang, Y., Li, Z., Li, L., Sun, B. (2024) Inhibitory Effects of Jiuzao Polysaccharides on Alcoholic Fatty Liver Formation in Zebrafish Larvae and Their Regulatory Impact on Intestinal Microbiota. Foods (Basel, Switzerland). 13(2):
- Li, X., Liu, C., Zhang, R., Li, Y., Ye, D., Wang, H., He, M., Sun, Y. (2024) Biosynthetic deficiency of docosahexaenoic acid causes nonalcoholic fatty liver disease and ferroptosis-mediated hepatocyte injury. The Journal of biological chemistry. 300(7):107405
- Yu, H.C., Bai, Q.R., Guo, J.J., Chen, M.Y., Wang, L., Tong, F.C., Zhang, S.L., Wu, J. (2024) Elucidating hydroxysafflor yellow A's multi-target mechanisms against alcoholic liver disease through integrative pharmacology. Phytomedicine : international journal of phytotherapy and phytopharmacology. 134:155956155956
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Shihana, F., Cholan, P.M., Fraser, S., Oehlers, S.H., Seth, D. (2023) Investigating the role of lipid genes in liver disease using fatty liver models of alcohol and high fat in zebrafish (Danio rerio). Liver international : official journal of the International Association for the Study of the Liver. 43(11):2455-2468
- Chen, S., Ye, W., Clements, K.D., Zan, Z., Zhao, W., Zou, H., Wang, G., Wu, S. (2022) Bacillus licheniformis FA6 Affects Zebrafish Lipid Metabolism through Promoting Acetyl-CoA Synthesis and Inhibiting β-Oxidation. International Journal of Molecular Sciences. 24(1):
- Ding, Q., Hao, Q., Zhang, Q., Yang, Y., Olsen, R.E., Ringø, E., Ran, C., Zhang, Z., Zhou, Z. (2022) DHA Suppresses Hepatic Lipid Accumulation via Cyclin D1 in Zebrafish. Frontiers in nutrition. 8:797510
- Hu, C., Sun, B., Liu, M., Yu, J., Zhou, X., Chen, L. (2022) Fecal transplantation from young zebrafish donors efficiently ameliorates the lipid metabolism disorder of aged recipients exposed to perfluorobutanesulfonate. The Science of the total environment. 823:153758
- Kamoshita, M., Kumar, R., Anteghini, M., Kunze, M., Islinger, M., Martins Dos Santos, V., Schrader, M. (2022) Insights Into the Peroxisomal Protein Inventory of Zebrafish. Frontiers in Physiology. 13:822509
- Yang, G., Sun, S., He, J., Wang, Y., Ren, T., He, H., Gao, J. (2022) Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase (ehhadh) is essential for production of DHA in zebrafish. Journal of Lipid Research. 64(3):100326
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