Gene
acsl5
- ID
- ZDB-GENE-040912-169
- Name
- acyl-CoA synthetase long chain family member 5
- Symbol
- acsl5 Nomenclature History
- Previous Names
-
- zgc:92083
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable arachidonate-CoA ligase activity. Predicted to be involved in long-chain fatty-acyl-CoA biosynthetic process and positive regulation of long-chain fatty acid import across plasma membrane. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be active in endoplasmic reticulum; membrane; and mitochondrion. Is expressed in brain; gill; liver; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human ACSL5 (acyl-CoA synthetase long chain family member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92083 (7 images)
- IMAGE:7163345 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ?Diarrhea 13 | 620357 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | AMP-binding, conserved site | AMP-dependent synthetase/ligase domain | ANL, N-terminal domain | Long-chain fatty acid CoA synthetase, eukaryotic |
|---|---|---|---|---|---|
|
UniProtKB:F1RAK0
|
681 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-167A11 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7163345 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92083 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001004599 (1) | 2329 nt | ||
| Genomic | GenBank:CU459185 (1) | 132093 nt | ||
| Polypeptide | UniProtKB:F1RAK0 (1) | 681 aa |
- Sun, W., Zhang, X., Qiao, Y., Griffin, N., Zhang, H., Wang, L., Liu, H. (2023) Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish. Ecotoxicology and environmental safety. 259:115020115020
- Kamoshita, M., Kumar, R., Anteghini, M., Kunze, M., Islinger, M., Martins Dos Santos, V., Schrader, M. (2022) Insights Into the Peroxisomal Protein Inventory of Zebrafish. Frontiers in Physiology. 13:822509
- Pottie, L., Van Gool, W., Vanhooydonck, M., Hanisch, F.G., Goeminne, G., Rajkovic, A., Coucke, P., Sips, P., Callewaert, B. (2021) Loss of zebrafish atp6v1e1b, encoding a subunit of vacuolar ATPase, recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures. PLoS Genetics. 17:e1009603
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Banerjee, B., Koner, D., Karasik, D., Saha, N. (2020) Genome-wide identification of novel long non-coding RNAs and their possible roles in hypoxic zebrafish brain. Genomics. 113(1 Pt 1):29-43
- Gu, Q., Ali, S.F., Kanungo, J. (2020) Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Journal of applied toxicology : JAT. 41(2):256-264
- Sheng, Y., Ren, H., Limbu, S.M., Sun, Y., Qiao, F., Zhai, W., Du, Z.Y., Zhang, M. (2018) The Presence or Absence of Intestinal Microbiota Affects Lipid Deposition and Related Genes Expression in Zebrafish (Danio rerio).. Frontiers in microbiology. 9:1124
- Quinlivan, V.H., Farber, S.A. (2017) Lipid Uptake, Metabolism, and Transport in the Larval Zebrafish. Frontiers in endocrinology. 8:319
- Khayrullin, A., Smith, L., Mistry, D., Dukes, A., Pan, Y.A., Hamrick, M.W. (2016) Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle. Biochemical and Biophysical Research Communications. 479(3):590-595
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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