Gene
cyp8b1.1
- ID
- ZDB-GENE-040808-53
- Name
- cytochrome P450 family 8 subfamily B member 1, tandem duplicate 1
- Symbol
- cyp8b1.1 Nomenclature History
- Previous Names
-
- cyp8b1 (1)
- si:ch73-198j8.4
- zgc:92406
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to enable sterol 12-alpha-hydroxylase activity. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in intestinal bulb and liver. Orthologous to human CYP8B1 (cytochrome P450 family 8 subfamily B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92406 (5 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017972 | Cytochrome P450, conserved site |
| Family | IPR001128 | Cytochrome P450 |
| Family | IPR002403 | Cytochrome P450, E-class, group IV |
| Family | IPR024204 | Cytochrome P450, cholesterol 7-alpha-monooxygenase-type |
| Homologous_superfamily | IPR036396 | Cytochrome P450 superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Cytochrome P450 | Cytochrome P450, cholesterol 7-alpha-monooxygenase-type | Cytochrome P450, conserved site | Cytochrome P450, E-class, group IV | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
| UniProtKB:Q6AZW0 | InterPro | 510 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp8b1-201
(1)
|
Ensembl | 1,975 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-198J8 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92406 | ZFIN Curated Data | |
| Has Artifact | EST | fb68e03 | ||
| Is Hybridized by | EST | fb67h05 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001003736 (1) | 2000 nt | ||
| Genomic | GenBank:CU694226 (1) | 83690 nt | ||
| Polypeptide | UniProtKB:Q6AZW0 (1) | 510 aa |
No data available
- Hu, C., Sun, B., Liu, M., Yu, J., Zhou, X., Chen, L. (2022) Fecal transplantation from young zebrafish donors efficiently ameliorates the lipid metabolism disorder of aged recipients exposed to perfluorobutanesulfonate. The Science of the total environment. 823:153758
- Wu, X., Xiong, F., Fang, H., Zhang, J., Chang, M. (2021) Crosstalks between NOD1 and Histone H2A Contribute to Host Defense against Streptococcus agalactiae Infection in Zebrafish. Antibiotics (Basel, Switzerland). 10(7):
- Chen, L., Lam, J.C., Tang, L., Hu, C., Liu, M., Lam, P.K.S., Zhou, B. (2020) Probiotic modulation of lipid metabolism disorders caused by perfluorobutanesulfonate pollution in zebrafish. Environmental science & technology. 54(12):7494-7503
- Hu, C., Liu, M., Wan, T., Tang, L., Sun, B., Zhou, B., Lam, J.C.W., Lam, P.K.S., Chen, L. (2020) Disturbances in Microbial and Metabolic Communication across the Gut-Liver Axis Induced by a Dioxin-like Pollutant: An Integrated Metagenomics and Metabolomics Analysis. Environmental science & technology. 55(1):529-537
- Kim, Y.C., Lee, S.R., Jeon, H.J., Kim, K., Kim, M.J., Choi, S.D., Lee, S.E. (2020) Acute toxicities of fluorene, fluorene-1-carboxylic acid, and fluorene-9-carboxylic acid on zebrafish embryos (Danio rerio): Molecular mechanisms of developmental toxicities of fluorene-1-carboxylic acid. Chemosphere. 260:127622
- Zhao, G., Zhang, T., Sun, H., Liu, J.X. (2019) Copper nanoparticles induce zebrafish intestinal defects via endoplasmic reticulum and oxidative stress. Metallomics : integrated biometal science. 12(1):12-22
- Lemaire, B., Kubota, A., O'Meara, C.M., Lamb, D.C., Tanguay, R.L., Goldstone, J.V., Stegeman, J.J. (2016) Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicology and applied pharmacology. 296:73-84
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Goldstone, J.V., McArthur, A.G., Kubota, A., Zanette, J., Parente, T., Jonsson, M.E., Nelson, D.R., and Stegeman, J.J. (2010) Identification and developmental expression of the full complement of cytochrome P450 genes in zebrafish. BMC Genomics. 11:643
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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