Gene
cd36
- ID
- ZDB-GENE-040718-55
- Name
- CD36 molecule (CD36 blood group)
- Symbol
- cd36 Nomenclature History
- Previous Names
-
- zgc:92513 (1)
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable low-density lipoprotein particle binding activity; low-density lipoprotein particle receptor activity; and scavenger receptor activity. Acts upstream of or within several processes, including defense response to bacterium; response to prostaglandin; and response to vitamin B3. Located in plasma membrane. Is expressed in several structures, including blastoderm; blastodisc; digestive system; pleuroperitoneal region; and taste bud. Human ortholog(s) of this gene implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human CD36 (CD36 molecule (CD36 blood group)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 35 figures from 23 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:92513 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| cq203 | Allele with one deletion | Exon 1 | Premature Stop | CRISPR | |
| cq204 | Allele with one deletion | Exon 1 | Premature Stop | CRISPR | |
| ihb260 | Allele with one delins | Unknown | Unknown | CRISPR | |
| ihb261 | Allele with one deletion | Exon 3 | Unknown | CRISPR | |
| ouc1001 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | TALEN | |
| sa9388 | Allele with one point mutation | Intron 10 | Splice Site, Cryptic Donor Splice Site, Exon Loss, Frameshift | ENU | |
| sa40295 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cd36 | Zebrafish Nomenclature Committee | |
| CRISPR2-cd36 | Xu et al., 2021 | |
| CRISPR3-cd36 | Keatinge et al., 2021 | |
| MO1-cd36 | N/A | (2) |
| MO2-cd36 | N/A | Fink et al., 2015 |
| TALEN1-cd36 | Liu et al., 2017 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| platelet-type bleeding disorder 10 | Alliance | Platelet glycoprotein IV deficiency | 608404 |
| {Coronary heart disease, susceptibility to, 7} | 610938 | ||
| {Malaria, cerebral, reduced risk of} | 611162 | ||
| {Malaria, cerebral, susceptibility to} | 611162 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CD36 family | CD36/scavenger receptor class B member 1 |
|---|---|---|---|---|
| UniProtKB:Q6DHC7 | InterPro | 465 |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(cd36:RFP) |
|
| 1 | (2) | |
| Tg(hsp70l:cd36-GFP,myl7:EGFP) |
| 1 | Levic et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-27K7 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:92513 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002363 (1) | 1737 nt | ||
| Genomic | GenBank:BX897665 (2) | 129995 nt | ||
| Polypeptide | UniProtKB:Q6DHC7 (1) | 465 aa |
- Du, Q., Shao, R., Wang, W., Zhang, H., Liao, X., Wang, Z., Yin, Z., Ai, Q., Mai, K., Tang, X., Wan, M. (2024) Vitamin D3 Regulates Energy Homeostasis under Short-Term Fasting Condition in Zebrafish (Danio Rerio). Nutrients. 16(9):
- Freeburg, S.H., Shwartz, A., Kemény, L.V., Smith, C.J., Weeks, O., Miller, B.M., PenkoffLidbeck, N., Fisher, D.E., Evason, K.J., Goessling, W. (2024) Hepatocyte vitamin D receptor functions as a nutrient sensor that regulates energy storage and tissue growth in zebrafish. Cell Reports. 43:114393114393
- Huang, Y., Chen, Y., Xie, H., Feng, Y., Chen, S., Bao, B. (2024) Effects of Inducible Nitric Oxide Synthase (iNOS) Gene Knockout on the Diversity, Composition, and Function of Gut Microbiota in Adult Zebrafish. Biology. 13(6):
- Le Mentec, H., Monniez, E., Legrand, A., Monvoisin, C., Lagadic-Gossmann, D., Podechard, N. (2023) A New In Vivo Zebrafish Bioassay Evaluating Liver Steatosis Identifies DDE as a Steatogenic Endocrine Disruptor, Partly through SCD1 Regulation. International Journal of Molecular Sciences. 24(4):
- Sun, W., Zhang, X., Qiao, Y., Griffin, N., Zhang, H., Wang, L., Liu, H. (2023) Exposure to PFOA and its novel analogs disrupts lipid metabolism in zebrafish. Ecotoxicology and environmental safety. 259:115020115020
- Dai, W., Wang, K., Zhen, X., Huang, Z., Liu, L. (2022) Magnesium isoglycyrrhizinate attenuates acute alcohol-induced hepatic steatosis in a zebrafish model by regulating lipid metabolism and ER stress. Nutrition & metabolism. 19:23
- Gao, Y., Jin, Q., Gao, C., Chen, Y., Sun, Z., Guo, G., Peng, J. (2022) Unraveling Differential Transcriptomes and Cell Types in Zebrafish Larvae Intestine and Liver. Cells. 11(20):
- Singh, M.K., Yadav, R., Bhaskar, A.K., Sengupta, S., Sachidanandan, C. (2022) A diet-independent zebrafish model for NAFLD recapitulates patient lipid profiles and offers a system for small molecule screening. Biochimica et biophysica acta. Molecular and cell biology of lipids. 1868(1):159246
- Verwilligen, R.A.F., Mulder, L., Rodenburg, F.J., Van Dijke, A., Hoekstra, M., Bussmann, J., Van Eck, M. (2022) Stabilin 1 and 2 are important regulators for cellular uptake of apolipoprotein B-containing lipoproteins in zebrafish. Atherosclerosis. 346:18-25
- Zhao, F., He, J., Tang, J., Cui, N., Shi, Y., Li, Z., Liu, S., Wang, Y., Ma, M., Zhao, C., Luo, L., Li, L. (2022) Brain milieu induces early microglial maturation through the BAX-Notch axis. Nature communications. 13:6117
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