Gene
acaa1
- ID
- ZDB-GENE-040704-48
- Name
- acetyl-CoA acyltransferase 1
- Symbol
- acaa1 Nomenclature History
- Previous Names
-
- zgc:92385
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable acetyl-CoA C-acyltransferase activity. Predicted to be involved in fatty acid beta-oxidation and phenylacetate catabolic process. Predicted to be active in peroxisome. Is expressed in gut; liver; subcutaneous fat; and visceral fat. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7151392 (4 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Thiolase | Thiolase, active site | Thiolase, acyl-enzyme intermediate active site | Thiolase, conserved site | Thiolase, C-terminal | Thiolase-like | Thiolase-like superfamily, Thiolase | Thiolase, N-terminal |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6GQN6 | InterPro | 418 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-225E5 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7151392 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:92385 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192971 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001002207 (1) | 1672 nt | ||
| Genomic | GenBank:CR762423 (1) | 40724 nt | ||
| Polypeptide | UniProtKB:Q6GQN6 (1) | 418 aa |
- Gao, X.M., Li, B., Wang, M.Y., Liu, H.D., Tang, L.P., Wang, F., Yan, D.M., Han, X.Y., Xu, L.X. (2022) Transcriptome analysis of developing zebrafish (Danio rerio) embryo following exposure to Gaudichaudione H reveals teratogenicity and cardiovascular defects caused by abnormal iron metabolism. Chemico-biological interactions. 361:109968
- Kamoshita, M., Kumar, R., Anteghini, M., Kunze, M., Islinger, M., Martins Dos Santos, V., Schrader, M. (2022) Insights Into the Peroxisomal Protein Inventory of Zebrafish. Frontiers in Physiology. 13:822509
- Yang, G., Sun, S., He, J., Wang, Y., Ren, T., He, H., Gao, J. (2022) Enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase (ehhadh) is essential for production of DHA in zebrafish. Journal of Lipid Research. 64(3):100326
- Zhang, Q., Sun, S., Zhang, Y., Wang, X., Li, Q. (2022) Identification of Scd5 as a functional regulator of visceral fat deposition and distribution. iScience. 25:103916
- Lai, C.Y., Yeh, K.Y., Lin, C.Y., Hsieh, Y.W., Lai, H.H., Chen, J.R., Hsu, C.C., Her, G.M. (2021) MicroRNA-21 Plays Multiple Oncometabolic Roles in the Process of NAFLD-Related Hepatocellular Carcinoma via PI3K/AKT, TGF-β, and STAT3 Signaling. Cancers. 13(5):
- Takashima, S., Takemoto, S., Toyoshi, K., Ohba, A., Shimozawa, N. (2021) Zebrafish model of human Zellweger syndrome reveals organ-specific accumulation of distinct fatty acid species and widespread gene expression changes. Molecular genetics and metabolism. 133(3):307-323
- Xu, H., Jiang, Y., Miao, X.M., Tao, Y.X., Xie, L., Li, Y. (2021) A Model Construction of Starvation Induces Hepatic Steatosis and Transcriptome Analysis in Zebrafish Larvae. Biology. 10(2):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Bui-Nguyen, T.M., Baer, C.E., Lewis, J.A., Yang, D., Lein, P.J., Jackson, D.A. (2015) Dichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio. BMC Genomics. 16:853
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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