Gene
fgf17
- ID
- ZDB-GENE-040621-1
- Name
- fibroblast growth factor 17
- Symbol
- fgf17 Nomenclature History
- Previous Names
-
- fgf17b
- zgc:101759
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Involved in anterior/posterior pattern specification; mesoderm development; and nervous system development. Acts upstream of or within negative regulation of endodermal cell fate specification. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including blastomere; cardiovascular system; forebrain; paraxial mesoderm; and sensory system. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 20 with or without anosmia. Orthologous to human FGF17 (fibroblast growth factor 17).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 12 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7139635 (100 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-fgf17 | Jin et al., 2024 | |
| MO1-fgf17 | N/A | Cao et al., 2004 |
| MO2-fgf17 | N/A | Cao et al., 2004 |
| MO3-fgf17 | N/A | Poulain et al., 2006 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 20 with or without anosmia | Alliance | Hypogonadotropic hypogonadism 20 with or without anosmia | 615270 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Cytokine IL1/FGF | Fibroblast growth factor family |
|---|---|---|---|---|
| UniProtKB:A0A8M2BJU5 | InterPro | 203 | ||
| UniProtKB:B2GR83 | InterPro | 215 | ||
| UniProtKB:Q6SJP8 | InterPro | 215 |
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Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-112O19 | ZFIN Curated Data | |
| Contained in | BAC | CH211-237H13 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7139635 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:101759 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192204 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_214808 (1) | 2052 nt | ||
| Genomic | GenBank:CU984584 | 136990 nt | ||
| Polypeptide | UniProtKB:B2GR83 (1) | 215 aa |
- Jin, S., Choe, C.P. (2024) A Potential Role of fgf4, fgf24, and fgf17 in Pharyngeal Pouch Formation in Zebrafish. Development & reproduction. 28:556555-65
- Cudak, N., López-Delgado, A.C., Keil, S., Knopf, F. (2023) Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene expression patterns : GEP. 48:119307
- Zhang, W., Scerbo, P., Delagrange, M., Candat, V., Mayr, V., Vriz, S., Distel, M., Ducos, B., Bensimon, D. (2022) Fgf8 dynamics and critical slowing down may account for the temperature independence of somitogenesis. Communications biology. 5:113
- Carroll, S.H., Macias Trevino, C., Li, E.B., Kawasaki, K., Myers, N., Hallett, S.A., Alhazmi, N., Cotney, J., Carstens, R.P., Liao, E.C. (2020) An Irf6-Esrp1/2 regulatory axis controls midface morphogenesis in vertebrates. Development (Cambridge, England). 147(24):
- Lee, S., Hesse, R., Tamaki, S., Garland, C., Pomerantz, J.H. (2020) Human ARF Specifically Inhibits Epimorphic Regeneration in the Zebrafish Heart. Genes. 11(6):
- Gallegos, T.F., Kamei, C.N., Rohly, M., Drummond, I.A. (2019) Fibroblast growth factor signaling mediates progenitor cell aggregation and nephron regeneration in the adult zebrafish kidney. Developmental Biology. 454(1):44-51
- Lal, P., Tanabe, H., Suster, M.L., Ailani, D., Kotani, Y., Muto, A., Itoh, M., Iwasaki, M., Wada, H., Yaksi, E., Kawakami, K. (2018) Identification of a neuronal population in the telencephalon essential for fear conditioning in zebrafish. BMC Biology. 16:45
- Nelson, A.C., Cutty, S.J., Gasiunas, S.N., Deplae, I., Stemple, D.L., Wardle, F.C. (2017) In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors. Cell Reports. 19:2782-2795
- Wan, J., Goldman, D. (2017) Opposing Actions of Fgf8a on Notch Signaling Distinguish Two Muller Glial Cell Populations that Contribute to Retina Growth and Regeneration. Cell Reports. 19:849-862
- Jimenez, L., Wang, J., Morrison, M.A., Whatcott, C., Soh, K.K., Warner, S., Bearss, D., Jette, C.A., Stewart, R.A. (2016) Phenotypic chemical screening using zebrafish neural crest reporters identifies retinoid acid as an inhibitor of epithelial morphogenesis. Disease models & mechanisms. 9(4):389-400
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