Gene
pik3cg
- ID
- ZDB-GENE-040426-2532
- Name
- phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
- Symbol
- pik3cg Nomenclature History
- Previous Names
-
- wu:fb15d07
- zgc:77033
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable 1-phosphatidylinositol-3-kinase activity; 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity; and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Acts upstream of or within neutrophil chemotaxis. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder; immunodeficiency 97; and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-pik3cg | N/A | (2) |
| MO2-pik3cg | N/A | (3) |
| MO3-pik3cg | N/A | Zhou et al., 2022 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 97 | Alliance | Immunodeficiency 97 with autoinflammation | 619802 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| Domain | IPR000341 | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain |
| Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| Domain | IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
| Domain | IPR002420 | C2 phosphatidylinositol 3-kinase-type domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-type fold | C2 domain superfamily | C2 phosphatidylinositol 3-kinase-type domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | Phosphatidylinositol 3-kinase, adaptor-binding domain | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain | Phosphatidylinositol kinase | Phosphoinositide 3-kinase, accessory (PIK) domain | Phosphoinositide 3-kinase, accessory (PIK) domain superfamily | PIK3 catalytic subunit gamma, adaptor-binding domain | Protein kinase-like domain superfamily | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PH51 | InterPro | 1091 | ||||||||||||||
| UniProtKB:A0A8M9Q5U7 | InterPro | 1113 | ||||||||||||||
| UniProtKB:Q6NTI2 | InterPro | 1098 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pik3cg-201
(1)
|
Ensembl | 4,762 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-134B5 | ZFIN Curated Data | |
| Encodes | EST | fb15d07 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:64029 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:77033 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213306 (1) | 4770 nt | ||
| Genomic | GenBank:CU928083 (1) | 107444 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q5U7 (1) | 1113 aa |
- Zhou, S., Liu, Z., Kawakami, A. (2022) A PI3Kγ signal regulates macrophage recruitment to injured tissue for regenerative cell survival. Development, growth & differentiation. 64(8):433-445
- Feng, N., Bian, Z., Zhang, X., Wang, C., Chen, J. (2018) Rapamycin reduces mortality in acute-stage paraquat-induced toxicity in zebrafish. Singapore medical journal. 60(5):241-246
- Zhang, Y.M., Zimmer, M.A., Guardia, T., Callahan, S.J., Mondal, C., Di Martino, J., Takagi, T., Fennell, M., Garippa, R., Campbell, N.R., Bravo-Cordero, J.J., White, R.M. (2018) Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2. Developmental Cell. 45(5):580-594.e7
- Sertori, R., Liongue, C., Basheer, F., Lewis, K.L., Rasighaemi, P., de Coninck, D., Traver, D., Ward, A.C. (2016) Conserved IL-2Rγc Signaling Mediates Lymphopoiesis in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 196(1):135-43
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kok, F.O., Shin, M., Ni, C., Gupta, A., Grosse, A.S., van Impel, A., Kirchmaier, B.C., Peterson-Maduro, J., Kourkoulis, G., Male, I., DeSantis, D.F., Sheppard-Tindell, S., Ebarasi, L., Betsholtz, C., Schulte-Merker, S., Wolfe, S.A., Lawson, N.D. (2015) Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish. Developmental Cell. 32(1):97-108
- Li, P., Lahvic, J.L., Binder, V., Pugach, E.K., Riley, E.B., Tamplin, O.J., Panigrahy, D., Bowman, T.V., Barrett, F.G., Heffner, G.C., McKinney-Freeman, S., Schlaeger, T.M., Daley, G.Q., Zeldin, D.C., Zon, L.I. (2015) Epoxyeicosatrienoic acids enhance embryonic haematopoiesis and adult marrow engraftment. Nature. 523:468-71
- Yoo, S.K., Deng, Q., Cavnar, P.J., Wu, Y.I., Hahn, K.M., and Huttenlocher, A. (2010) Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish. Developmental Cell. 18(2):226-236
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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