Gene
pik3cg
- ID
- ZDB-GENE-040426-2532
- Name
- phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
- Symbol
- pik3cg Nomenclature History
- Previous Names
-
- wu:fb15d07
- zgc:77033
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Acts upstream of or within neutrophil chemotaxis. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA and phosphatidylinositol 3-kinase complex, class IB. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in autistic disorder; primary immunodeficiency disease; and swine influenza. Orthologous to human PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 97 | Alliance | Immunodeficiency 97 with autoinflammation | 619802 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018936 | Phosphatidylinositol 3/4-kinase, conserved site |
| Domain | IPR000341 | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain |
| Domain | IPR000403 | Phosphatidylinositol 3-/4-kinase, catalytic domain |
| Domain | IPR001263 | Phosphoinositide 3-kinase, accessory (PIK) domain |
| Domain | IPR002420 | C2 phosphatidylinositol 3-kinase-type domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo-type fold | C2 domain superfamily | C2 phosphatidylinositol 3-kinase-type domain | Phosphatidylinositol 3-/4-kinase, catalytic domain | Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily | Phosphatidylinositol 3/4-kinase, conserved site | Phosphatidylinositol 3-kinase, adaptor-binding domain | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain | Phosphatidylinositol kinase | Phosphoinositide 3-kinase, accessory (PIK) domain | Phosphoinositide 3-kinase, accessory (PIK) domain superfamily | PIK3 catalytic subunit gamma, adaptor-binding domain | Protein kinase-like domain superfamily | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PH51 | InterPro | 1091 | ||||||||||||||
| UniProtKB:A0A8M9Q5U7 | InterPro | 1113 | ||||||||||||||
| UniProtKB:Q6NTI2 | InterPro | 1098 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pik3cg-201
(1)
|
Ensembl | 4,762 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available