Gene
pck2
- ID
- ZDB-GENE-040426-2266
- Name
- phosphoenolpyruvate carboxykinase 2 (mitochondrial)
- Symbol
- pck2 Nomenclature History
- Previous Names
-
- id:ibd5157
- zgc:77867
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable manganese ion binding activity and phosphoenolpyruvate carboxykinase (GTP) activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; cellular response to dexamethasone stimulus; and gluconeogenesis. Predicted to be active in cytosol and mitochondrion. Is expressed in extension; intestinal bulb; liver; and yolk syncytial layer. Orthologous to human PCK2 (phosphoenolpyruvate carboxykinase 2, mitochondrial).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 24 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7152622 (13 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| PEPCK deficiency, mitochondrial | 261650 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018091 | Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site |
| Domain | IPR035077 | Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain |
| Domain | IPR035078 | Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal |
| Family | IPR008209 | Phosphoenolpyruvate carboxykinase, GTP-utilising |
| Homologous_superfamily | IPR008210 | Phosphoenolpyruvate carboxykinase, N-terminal |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Phosphoenolpyruvate carboxykinase, C-terminal | Phosphoenolpyruvate carboxykinase, C-terminal P-loop domain | Phosphoenolpyruvate carboxykinase, GTP-utilising | Phosphoenolpyruvate carboxykinase, GTP-utilising, conserved site | Phosphoenolpyruvate carboxykinase, GTP-utilising, N-terminal | Phosphoenolpyruvate carboxykinase, N-terminal |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q6P3H6 | InterPro | 636 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-28D2 | ZFIN Curated Data | |
| Encodes | EST | ibd5157 | Kudoh et al., 2001 | |
| Encodes | EST | IMAGE:7152622 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:77867 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_213192 (1) | 3067 nt | ||
| Genomic | GenBank:BX247906 (1) | 213917 nt | ||
| Polypeptide | UniProtKB:Q6P3H6 (1) | 636 aa |
- Chen, J., Ji, X., Gao, J., Huang, J., Ren, J. (2024) gys1 regulates maternal glycogen reserve essential for embryonic development in zebrafish. Heliyon. 10:e31149e31149
- Chen, J., Zhao, W., Cao, L., Martins, R.S.T., Canário, A.V.M. (2024) Somatostatin signalling coordinates energy metabolism allocation to reproduction in zebrafish. BMC Biology. 22:163163
- Hu, T., Liu, L., Wang, H., Yang, M., Xu, B., Xie, H., Lin, Z., Jin, X., Wang, P., Liu, Y., Sun, H., Liu, S. (2024) RCAN family member 3 deficiency contributes to noncompaction of the ventricular myocardium. Journal of genetics and genomics = Yi chuan xue bao. 51(5):543-553
- Hu, W., Liu, L., Forn-Cuní, G., Ding, Y., Alia, A., Spaink, H.P. (2023) Transcriptomic and Metabolomic Studies Reveal That Toll-like Receptor 2 Has a Role in Glucose-Related Metabolism in Unchallenged Zebrafish Larvae (Danio rerio). Biology. 12(2):
- Li, Y., Liu, C., Bai, X., Li, M., Duan, C. (2023) FK506-binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium. FEBS letters. 597(14):1868-1879
- Xi, L., Lu, Q., Liu, Y., Gong, Y., Liu, H., Jin, J., Zhang, Z., Yang, Y., Zhu, X., Han, D., Xie, S. (2023) Study on Carbohydrate Metabolism in Adult Zebrafish (Danio rerio). Aquaculture nutrition. 2023:13975081397508
- Li, L., Chen, M., Liu, W., Tai, P., Liu, X., Liu, J.X. (2022) Zebrafish cox17 modulates primitive erythropoiesis via regulation of mitochondrial metabolism to facilitate hypoxia tolerance. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22596
- Pozo-Morales, M., Garteizgogeascoa, I., Perazzolo, C., So, J., Shin, D., Singh, S.P. (2022) In vivo imaging of calcium dynamics in zebrafish hepatocytes. Hepatology (Baltimore, Md.). 77(3):789-801
- Tabler, C.T., Lodd, E., Bennewitz, K., Middel, C.S., Erben, V., Ott, H., Poth, T., Fleming, T., Morgenstern, J., Hausser, I., Sticht, C., Poschet, G., Szendroedi, J., Nawroth, P.P., Kroll, J. (2022) Loss of glyoxalase 2 alters the glucose metabolism in zebrafish. Redox Biology. 59:102576102576
- Banerji, R., Huynh, C., Figueroa, F., Dinday, M.T., Baraban, S.C., Patel, M. (2021) Enhancing glucose metabolism via gluconeogenesis is therapeutic in a zebrafish model of Dravet syndrome. Brain communications. 3:fcab004
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